| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0002 | Meso_0873 | Meso_0002 | Meso_0873 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | 0.892 |
| Meso_0002 | Meso_0987 | Meso_0002 | Meso_0987 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.820 |
| Meso_0002 | Meso_1204 | Meso_0002 | Meso_1204 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: DnaB-like helicase-like; KEGG: atc:AGR_C_2006 replicative DNA helicase. | 0.806 |
| Meso_0002 | Meso_2226 | Meso_0002 | Meso_2226 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, epsilon subunit; KEGG: mag:amb1544 predicted signal-transduction protein containing cAMP-binding and CBS domains; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: CBS domain containing protein Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease. | 0.992 |
| Meso_0002 | recF | Meso_0002 | Meso_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.975 |
| Meso_0002 | rnpA | Meso_0002 | Meso_0375 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.572 |
| Meso_0002 | rplB | Meso_0002 | Meso_1675 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.548 |
| Meso_0871 | Meso_0873 | Meso_0871 | Meso_0873 | PFAM: ROSMUCR transcriptional regulator; KEGG: mlo:mlr7645 transcriptional regulator. | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | 0.473 |
| Meso_0872 | Meso_0873 | Meso_0872 | Meso_0873 | KEGG: bme:BMEI1363 hypothetical cytosolic protein. | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | 0.559 |
| Meso_0872 | Meso_0874 | Meso_0872 | Meso_0874 | KEGG: bme:BMEI1363 hypothetical cytosolic protein. | KEGG: bme:BMEI1361 hypothetical cytosolic protein. | 0.560 |
| Meso_0873 | Meso_0002 | Meso_0873 | Meso_0002 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.892 |
| Meso_0873 | Meso_0871 | Meso_0873 | Meso_0871 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | PFAM: ROSMUCR transcriptional regulator; KEGG: mlo:mlr7645 transcriptional regulator. | 0.473 |
| Meso_0873 | Meso_0872 | Meso_0873 | Meso_0872 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | KEGG: bme:BMEI1363 hypothetical cytosolic protein. | 0.559 |
| Meso_0873 | Meso_0874 | Meso_0873 | Meso_0874 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | KEGG: bme:BMEI1361 hypothetical cytosolic protein. | 0.844 |
| Meso_0873 | Meso_0987 | Meso_0873 | Meso_0987 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.674 |
| Meso_0873 | Meso_1204 | Meso_0873 | Meso_1204 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | PFAM: DnaB-like helicase-like; KEGG: atc:AGR_C_2006 replicative DNA helicase. | 0.674 |
| Meso_0873 | Meso_2226 | Meso_0873 | Meso_2226 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | DNA polymerase III, epsilon subunit; KEGG: mag:amb1544 predicted signal-transduction protein containing cAMP-binding and CBS domains; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: CBS domain containing protein Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease. | 0.480 |
| Meso_0873 | recF | Meso_0873 | Meso_0003 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.560 |
| Meso_0873 | rnpA | Meso_0873 | Meso_0375 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.463 |
| Meso_0873 | rplB | Meso_0873 | Meso_1675 | PFAM: Chromosomal replication initiator, DnaA-like; KEGG: bmb:BruAb1_0593 hypothetical protein. | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.495 |
