| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0901 | Meso_0902 | Meso_0901 | Meso_0902 | TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap PDZ/DHR/GLGF; KEGG: mlo:mlr7692 serine protease; Belongs to the peptidase S1C family. | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | 0.719 |
| Meso_0901 | Meso_0903 | Meso_0901 | Meso_0903 | TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap PDZ/DHR/GLGF; KEGG: mlo:mlr7692 serine protease; Belongs to the peptidase S1C family. | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | 0.726 |
| Meso_0901 | glnE | Meso_0901 | Meso_0904 | TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap PDZ/DHR/GLGF; KEGG: mlo:mlr7692 serine protease; Belongs to the peptidase S1C family. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.546 |
| Meso_0902 | Meso_0901 | Meso_0902 | Meso_0901 | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap PDZ/DHR/GLGF; KEGG: mlo:mlr7692 serine protease; Belongs to the peptidase S1C family. | 0.719 |
| Meso_0902 | Meso_0903 | Meso_0902 | Meso_0903 | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | 0.974 |
| Meso_0902 | Meso_1942 | Meso_0902 | Meso_1942 | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: ppu:PP3761 sensor histidine kinase/response regulator. | 0.884 |
| Meso_0902 | glnE | Meso_0902 | Meso_0904 | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.725 |
| Meso_0903 | Meso_0901 | Meso_0903 | Meso_0901 | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap PDZ/DHR/GLGF; KEGG: mlo:mlr7692 serine protease; Belongs to the peptidase S1C family. | 0.726 |
| Meso_0903 | Meso_0902 | Meso_0903 | Meso_0902 | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | 0.974 |
| Meso_0903 | Meso_1942 | Meso_0903 | Meso_1942 | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: ppu:PP3761 sensor histidine kinase/response regulator. | 0.576 |
| Meso_0903 | glnE | Meso_0903 | Meso_0904 | Periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like; KEGG: mlo:mlr7697 two-component, sensor histidine kinase. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.721 |
| Meso_1544 | Meso_1942 | Meso_1544 | Meso_1942 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp; KEGG: sme:SMc00948 glutamine synthetase I protein. | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: ppu:PP3761 sensor histidine kinase/response regulator. | 0.498 |
| Meso_1544 | Meso_2744 | Meso_1544 | Meso_2744 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp; KEGG: sme:SMc00948 glutamine synthetase I protein. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.964 |
| Meso_1544 | glnE | Meso_1544 | Meso_0904 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp; KEGG: sme:SMc00948 glutamine synthetase I protein. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.595 |
| Meso_1619 | Meso_1942 | Meso_1619 | Meso_1942 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like PAS fold; SMART: PAS; KEGG: mlo:mlr0397 nitrogen reguration protein nirB protein. | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: ppu:PP3761 sensor histidine kinase/response regulator. | 0.826 |
| Meso_1619 | Meso_2744 | Meso_1619 | Meso_2744 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like PAS fold; SMART: PAS; KEGG: mlo:mlr0397 nitrogen reguration protein nirB protein. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.459 |
| Meso_1619 | glnD | Meso_1619 | Meso_4033 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like PAS fold; SMART: PAS; KEGG: mlo:mlr0397 nitrogen reguration protein nirB protein. | UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.600 |
| Meso_1619 | glnE | Meso_1619 | Meso_0904 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like PAS fold; SMART: PAS; KEGG: mlo:mlr0397 nitrogen reguration protein nirB protein. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.505 |
| Meso_1787 | glnE | Meso_1787 | Meso_0904 | PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Redoxin; KEGG: mlo:mll0004 bacterioferritin. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.671 |
| Meso_1942 | Meso_0902 | Meso_1942 | Meso_0902 | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: ppu:PP3761 sensor histidine kinase/response regulator. | Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver transcriptional regulatory protein-like; KEGG: mlo:mlr7695 two-component response regulator. | 0.884 |
