| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0593 | Meso_1626 | Meso_0593 | Meso_1626 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | 0.815 |
| Meso_0593 | Meso_2028 | Meso_0593 | Meso_2028 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.542 |
| Meso_0593 | Meso_3400 | Meso_0593 | Meso_3400 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A fumarate reductase/succinate dehydrogenase flavoprotein-like pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mll4296 dihydrolipoamide dehydrogenase. | 0.815 |
| Meso_0593 | folD | Meso_0593 | Meso_0152 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.684 |
| Meso_0593 | gcvH | Meso_0593 | Meso_1017 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.986 |
| Meso_0593 | gcvP | Meso_0593 | Meso_1016 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| Meso_0593 | glyA | Meso_0593 | Meso_1134 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| Meso_1018 | Meso_1626 | Meso_1018 | Meso_1626 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | 0.968 |
| Meso_1018 | Meso_2028 | Meso_1018 | Meso_2028 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.923 |
| Meso_1018 | Meso_3400 | Meso_1018 | Meso_3400 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A fumarate reductase/succinate dehydrogenase flavoprotein-like pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mll4296 dihydrolipoamide dehydrogenase. | 0.972 |
| Meso_1018 | folD | Meso_1018 | Meso_0152 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
| Meso_1018 | gcvH | Meso_1018 | Meso_1017 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| Meso_1018 | gcvP | Meso_1018 | Meso_1016 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| Meso_1018 | glyA | Meso_1018 | Meso_1134 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| Meso_1018 | lipA | Meso_1018 | Meso_1624 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.526 |
| Meso_1018 | thyA | Meso_1018 | Meso_1751 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.914 |
| Meso_1626 | Meso_0593 | Meso_1626 | Meso_0593 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | 0.815 |
| Meso_1626 | Meso_1018 | Meso_1626 | Meso_1018 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | 0.968 |
| Meso_1626 | Meso_2028 | Meso_1626 | Meso_2028 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.911 |
| Meso_1626 | Meso_3400 | Meso_1626 | Meso_3400 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A fumarate reductase/succinate dehydrogenase flavoprotein-like pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mll4296 dihydrolipoamide dehydrogenase. | 0.910 |
