| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_1018 | Meso_0328 | Meso_1018 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | 0.944 |
| Meso_0328 | Meso_2028 | Meso_0328 | Meso_2028 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.994 |
| Meso_0328 | fhs | Meso_0328 | Meso_2204 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.961 |
| Meso_0328 | folD | Meso_0328 | Meso_0152 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.606 |
| Meso_0328 | gcvH | Meso_0328 | Meso_1017 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.718 |
| Meso_0328 | gcvP | Meso_0328 | Meso_1016 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.632 |
| Meso_0328 | glyA | Meso_0328 | Meso_1134 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
| Meso_0328 | purH | Meso_0328 | Meso_3420 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.914 |
| Meso_1018 | Meso_0328 | Meso_1018 | Meso_0328 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.944 |
| Meso_1018 | Meso_1626 | Meso_1018 | Meso_1626 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | 0.968 |
| Meso_1018 | Meso_2028 | Meso_1018 | Meso_2028 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.923 |
| Meso_1018 | Meso_3400 | Meso_1018 | Meso_3400 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A fumarate reductase/succinate dehydrogenase flavoprotein-like pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mll4296 dihydrolipoamide dehydrogenase. | 0.972 |
| Meso_1018 | fhs | Meso_1018 | Meso_2204 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.934 |
| Meso_1018 | folD | Meso_1018 | Meso_0152 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
| Meso_1018 | gcvH | Meso_1018 | Meso_1017 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| Meso_1018 | gcvP | Meso_1018 | Meso_1016 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| Meso_1018 | glyA | Meso_1018 | Meso_1134 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| Meso_1018 | purH | Meso_1018 | Meso_3420 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.930 |
| Meso_1626 | Meso_1018 | Meso_1626 | Meso_1018 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | 0.968 |
| Meso_1626 | Meso_2028 | Meso_1626 | Meso_2028 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region FAD dependent oxidoreductase; KEGG: mlo:mlr0388 dihydrolipoamide dehydrogenase. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.911 |
