| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0593 | Meso_1367 | Meso_0593 | Meso_1367 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.695 |
| Meso_0593 | Meso_2028 | Meso_0593 | Meso_2028 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.542 |
| Meso_0593 | fhs | Meso_0593 | Meso_2204 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.682 |
| Meso_0593 | folD | Meso_0593 | Meso_0152 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.684 |
| Meso_0593 | gcvH | Meso_0593 | Meso_1017 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.986 |
| Meso_0593 | gcvP | Meso_0593 | Meso_1016 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| Meso_0593 | glyA | Meso_0593 | Meso_1134 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| Meso_1018 | Meso_2028 | Meso_1018 | Meso_2028 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.923 |
| Meso_1018 | fhs | Meso_1018 | Meso_2204 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.934 |
| Meso_1018 | folD | Meso_1018 | Meso_0152 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
| Meso_1018 | gcvH | Meso_1018 | Meso_1017 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| Meso_1018 | gcvP | Meso_1018 | Meso_1016 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| Meso_1018 | glyA | Meso_1018 | Meso_1134 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| Meso_1018 | purH | Meso_1018 | Meso_3420 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.930 |
| Meso_1018 | purN | Meso_1018 | Meso_1967 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.921 |
| Meso_1367 | Meso_0593 | Meso_1367 | Meso_0593 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | 0.695 |
| Meso_1367 | gcvH | Meso_1367 | Meso_1017 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.444 |
| Meso_1367 | gcvP | Meso_1367 | Meso_1016 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.709 |
| Meso_1367 | glyA | Meso_1367 | Meso_1134 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| Meso_2028 | Meso_0593 | Meso_2028 | Meso_0593 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | 0.542 |
