| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1136 | Meso_1137 | Meso_1136 | Meso_1137 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 0.999 |
| Meso_1136 | Meso_1140 | Meso_1136 | Meso_1140 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 0.751 |
| Meso_1136 | Meso_1412 | Meso_1136 | Meso_1412 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.781 |
| Meso_1136 | Meso_1414 | Meso_1136 | Meso_1414 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: mlo:mll0786 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.769 |
| Meso_1136 | Meso_1716 | Meso_1136 | Meso_1716 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.836 |
| Meso_1136 | eno | Meso_1136 | Meso_1632 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.867 |
| Meso_1136 | nrdR | Meso_1136 | Meso_1135 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Ribonucleotide reductase regulator NrdR-like protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.882 |
| Meso_1136 | nusB | Meso_1136 | Meso_1139 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.895 |
| Meso_1136 | ribB | Meso_1136 | Meso_0731 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| Meso_1136 | ribH | Meso_1136 | Meso_1138 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.995 |
| Meso_1137 | Meso_1136 | Meso_1137 | Meso_1136 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| Meso_1137 | Meso_1140 | Meso_1137 | Meso_1140 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 0.747 |
| Meso_1137 | Meso_1412 | Meso_1137 | Meso_1412 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.653 |
| Meso_1137 | Meso_1414 | Meso_1137 | Meso_1414 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: mlo:mll0786 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.566 |
| Meso_1137 | nrdR | Meso_1137 | Meso_1135 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | Ribonucleotide reductase regulator NrdR-like protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.779 |
| Meso_1137 | nusB | Meso_1137 | Meso_1139 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.741 |
| Meso_1137 | ribB | Meso_1137 | Meso_0731 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.998 |
| Meso_1137 | ribH | Meso_1137 | Meso_1138 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| Meso_1140 | Meso_1136 | Meso_1140 | Meso_1136 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.751 |
| Meso_1140 | Meso_1137 | Meso_1140 | Meso_1137 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 0.747 |