| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1136 | Meso_1137 | Meso_1136 | Meso_1137 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 0.999 |
| Meso_1136 | Meso_1140 | Meso_1136 | Meso_1140 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 0.751 |
| Meso_1136 | Meso_2580 | Meso_1136 | Meso_2580 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.553 |
| Meso_1136 | glyA | Meso_1136 | Meso_1134 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.682 |
| Meso_1136 | hppA | Meso_1136 | Meso_1141 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.577 |
| Meso_1136 | nrdR | Meso_1136 | Meso_1135 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Ribonucleotide reductase regulator NrdR-like protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.882 |
| Meso_1136 | nusB | Meso_1136 | Meso_1139 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.895 |
| Meso_1136 | ribH | Meso_1136 | Meso_1138 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.995 |
| Meso_1137 | Meso_1136 | Meso_1137 | Meso_1136 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| Meso_1137 | Meso_1140 | Meso_1137 | Meso_1140 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 0.747 |
| Meso_1137 | glyA | Meso_1137 | Meso_1134 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.654 |
| Meso_1137 | hppA | Meso_1137 | Meso_1141 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | 0.490 |
| Meso_1137 | nrdR | Meso_1137 | Meso_1135 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | Ribonucleotide reductase regulator NrdR-like protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.779 |
| Meso_1137 | nusB | Meso_1137 | Meso_1139 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.741 |
| Meso_1137 | ribH | Meso_1137 | Meso_1138 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| Meso_1140 | Meso_1136 | Meso_1140 | Meso_1136 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.751 |
| Meso_1140 | Meso_1137 | Meso_1140 | Meso_1137 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mlo:mlr8407 riboflavin synthase alpha chain. | 0.747 |
| Meso_1140 | Meso_2580 | Meso_1140 | Meso_2580 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.423 |
| Meso_1140 | Meso_2600 | Meso_1140 | Meso_2600 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | TIGRFAM: type I secretion membrane fusion protein, HlyD family; PFAM: secretion protein HlyD; KEGG: sme:SMc03146 putative transport protein. | 0.427 |
| Meso_1140 | glyA | Meso_1140 | Meso_1134 | PFAM: major facilitator superfamily MFS_1; KEGG: mlo:mlr8412 hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.561 |
