| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1351 | Meso_1352 | Meso_1351 | Meso_1352 | PFAM: NUDIX hydrolase; KEGG: mlo:mlr0843 hypothetical protein. | PFAM: protein of unknown function DUF983; KEGG: mlo:mlr0842 hypothetical protein. | 0.849 |
| Meso_1351 | rnr | Meso_1351 | Meso_1353 | PFAM: NUDIX hydrolase; KEGG: mlo:mlr0843 hypothetical protein. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.884 |
| Meso_1351 | topA | Meso_1351 | Meso_1354 | PFAM: NUDIX hydrolase; KEGG: mlo:mlr0843 hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.799 |
| Meso_1352 | Meso_1351 | Meso_1352 | Meso_1351 | PFAM: protein of unknown function DUF983; KEGG: mlo:mlr0842 hypothetical protein. | PFAM: NUDIX hydrolase; KEGG: mlo:mlr0843 hypothetical protein. | 0.849 |
| Meso_1352 | rnr | Meso_1352 | Meso_1353 | PFAM: protein of unknown function DUF983; KEGG: mlo:mlr0842 hypothetical protein. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.806 |
| Meso_1352 | topA | Meso_1352 | Meso_1354 | PFAM: protein of unknown function DUF983; KEGG: mlo:mlr0842 hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.833 |
| Meso_3984 | pnp | Meso_3984 | Meso_3935 | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.728 |
| Meso_3984 | rnr | Meso_3984 | Meso_1353 | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.916 |
| Meso_3984 | rph | Meso_3984 | Meso_4016 | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.915 |
| Meso_3984 | rpsG | Meso_3984 | Meso_1682 | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.663 |
| Meso_3984 | rpsQ | Meso_3984 | Meso_1669 | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.678 |
| pnp | Meso_3984 | Meso_3935 | Meso_3984 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | PFAM: 3'-5' exonuclease; KEGG: mlo:mll3296 hypothetical proteins, contains similarity to Ribonuclease D. | 0.728 |
| pnp | rnd | Meso_3935 | Meso_1121 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 0.791 |
| pnp | rnr | Meso_3935 | Meso_1353 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.853 |
| pnp | rph | Meso_3935 | Meso_4016 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.808 |
| pnp | rpsG | Meso_3935 | Meso_1682 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.762 |
| pnp | rpsQ | Meso_3935 | Meso_1669 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.447 |
| pnp | rpsR | Meso_3935 | Meso_1917 | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. | 0.489 |
| rnd | pnp | Meso_1121 | Meso_3935 | Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 3' exoribonuclease; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.791 |
| rnd | rnr | Meso_1121 | Meso_1353 | Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.936 |
