| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1336 | Meso_1373 | Meso_1336 | Meso_1373 | PFAM: peptidase S14, ClpP; KEGG: pae:PA3326 probable Clp-family ATP-dependent protease; Belongs to the peptidase S14 family. | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | 0.870 |
| Meso_1336 | clpX | Meso_1336 | Meso_1170 | PFAM: peptidase S14, ClpP; KEGG: pae:PA3326 probable Clp-family ATP-dependent protease; Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.960 |
| Meso_1336 | dnaK | Meso_1336 | Meso_0679 | PFAM: peptidase S14, ClpP; KEGG: pae:PA3326 probable Clp-family ATP-dependent protease; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.428 |
| Meso_1336 | grpE | Meso_1336 | Meso_4019 | PFAM: peptidase S14, ClpP; KEGG: pae:PA3326 probable Clp-family ATP-dependent protease; Belongs to the peptidase S14 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.454 |
| Meso_1373 | Meso_1336 | Meso_1373 | Meso_1336 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | PFAM: peptidase S14, ClpP; KEGG: pae:PA3326 probable Clp-family ATP-dependent protease; Belongs to the peptidase S14 family. | 0.870 |
| Meso_1373 | Meso_2276 | Meso_1373 | Meso_2276 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | PFAM: heat shock protein Hsp20; KEGG: sme:SMa1118 probable HspC2 heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.779 |
| Meso_1373 | clpP1 | Meso_1373 | Meso_1169 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.898 |
| Meso_1373 | clpP2 | Meso_1373 | Meso_1531 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.898 |
| Meso_1373 | clpS | Meso_1373 | Meso_1372 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.986 |
| Meso_1373 | clpS-2 | Meso_1373 | Meso_2130 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.929 |
| Meso_1373 | clpX | Meso_1373 | Meso_1170 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.796 |
| Meso_1373 | dnaJ | Meso_1373 | Meso_0680 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.882 |
| Meso_1373 | dnaK | Meso_1373 | Meso_0679 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
| Meso_1373 | grpE | Meso_1373 | Meso_4019 | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.774 |
| Meso_2276 | Meso_1373 | Meso_2276 | Meso_1373 | PFAM: heat shock protein Hsp20; KEGG: sme:SMa1118 probable HspC2 heat shock protein; Belongs to the small heat shock protein (HSP20) family. | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | 0.779 |
| Meso_2276 | dnaK | Meso_2276 | Meso_0679 | PFAM: heat shock protein Hsp20; KEGG: sme:SMa1118 probable HspC2 heat shock protein; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.587 |
| Meso_2276 | grpE | Meso_2276 | Meso_4019 | PFAM: heat shock protein Hsp20; KEGG: sme:SMa1118 probable HspC2 heat shock protein; Belongs to the small heat shock protein (HSP20) family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.509 |
| clpP1 | Meso_1373 | Meso_1169 | Meso_1373 | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central region Clp, N terminal ATPase associated with various cellular activities, AAA_5 ATPase AAA-2; SMART: ATPase; Belongs to the ClpA/ClpB family. | 0.898 |
| clpP1 | clpX | Meso_1169 | Meso_1170 | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.995 |
| clpP1 | dnaK | Meso_1169 | Meso_0679 | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.549 |
