| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0823 | Meso_1062 | Meso_0823 | Meso_1062 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | 0.409 |
| Meso_0823 | Meso_1488 | Meso_0823 | Meso_1488 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | 0.452 |
| Meso_0823 | Meso_1489 | Meso_0823 | Meso_1489 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT; KEGG: mlo:mll1432 acetolactate synthase small subunit. | 0.866 |
| Meso_0823 | Meso_2924 | Meso_0823 | Meso_2924 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: eba:ebA5686 acetolactate synthase large subunit. | 0.462 |
| Meso_0823 | Meso_3304 | Meso_0823 | Meso_3304 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mpa:MAP3000c acetolactate synthase large subunit. | 0.431 |
| Meso_0823 | Meso_3590 | Meso_0823 | Meso_3590 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: ret:RHE_PF00274 acetolactate synthase, large subunit protein (thiamine pyrophosphate-dependent enzyme). | 0.445 |
| Meso_0823 | ilvC | Meso_0823 | Meso_1496 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.961 |
| Meso_0823 | ilvD | Meso_0823 | Meso_1688 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.507 |
| Meso_0823 | ilvD-2 | Meso_0823 | Meso_2666 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.456 |
| Meso_1062 | Meso_0823 | Meso_1062 | Meso_0823 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 0.409 |
| Meso_1062 | Meso_1489 | Meso_1062 | Meso_1489 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT; KEGG: mlo:mll1432 acetolactate synthase small subunit. | 0.876 |
| Meso_1062 | ilvC | Meso_1062 | Meso_1496 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.970 |
| Meso_1062 | ilvD | Meso_1062 | Meso_1688 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.747 |
| Meso_1062 | ilvD-2 | Meso_1062 | Meso_2666 | Acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: bme:BMEII0351 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.556 |
| Meso_1488 | Meso_0823 | Meso_1488 | Meso_0823 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 0.452 |
| Meso_1488 | Meso_1489 | Meso_1488 | Meso_1489 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT; KEGG: mlo:mll1432 acetolactate synthase small subunit. | 0.998 |
| Meso_1488 | ilvC | Meso_1488 | Meso_1496 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.988 |
| Meso_1488 | ilvD | Meso_1488 | Meso_1688 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.868 |
| Meso_1488 | ilvD-2 | Meso_1488 | Meso_2666 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.810 |
| Meso_1489 | Meso_0823 | Meso_1489 | Meso_0823 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT; KEGG: mlo:mll1432 acetolactate synthase small subunit. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. | 0.866 |
