Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (486 aa)    
Predicted Functional Partners:
Meso_1619
Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like PAS fold; SMART: PAS; KEGG: mlo:mlr0397 nitrogen reguration protein nirB protein.
 0.998
Meso_1620
tRNA-U20-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
  
  
 0.853
Meso_2956
RNA polymerase, sigma 54 subunit, RpoN/SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.796
Meso_3667
RNA polymerase, sigma 54 subunit, RpoN/SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.796
Meso_1617
Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like PAS fold; KEGG: mlo:mlr0399 nitrogen regulation protein ntrY.
 
 
 0.785
Meso_0600
CheA signal transduction histidine kinase; PFAM: response regulator receiver CheW-like protein ATP-binding region, ATPase-like Hpt; KEGG: sme:SMa1558 putative histidine kinase, chemotaxis.
  
 
 0.749
Meso_1616
Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver sigma-54 factor, interaction region helix-turn-helix, Fis-type ATPase associated with various cellular activities, AAA_5; SMART: ATPase; KEGG: mlo:mlr0400 nitrogen assimilation regulatory protein NtrX.
 
    
0.654
Meso_0304
PFAM: surface presentation of antigens (SPOA) protein; KEGG: mlo:mll2904 flagellar motor switch protein FliM.
  
  
 0.629
ispDF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
       0.613
Meso_1622
PFAM: CinA-like; KEGG: rpb:RPB_2886 CinA-like; Belongs to the CinA family.
       0.590
Your Current Organism:
Chelativorans sp. BNC1
NCBI taxonomy Id: 266779
Other names: C. sp. BNC1, Mesorhizobium sp. BNC1
Server load: low (30%) [HD]