| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0022 | Meso_1523 | Meso_0022 | Meso_1523 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.844 |
| Meso_0022 | Meso_1628 | Meso_0022 | Meso_1628 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.920 |
| Meso_0022 | Meso_1646 | Meso_0022 | Meso_1646 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: mlo:mlr0629 citrate synthase; Belongs to the citrate synthase family. | 0.937 |
| Meso_0022 | Meso_3357 | Meso_0022 | Meso_3357 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.470 |
| Meso_0022 | acsA | Meso_0022 | Meso_3431 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.922 |
| Meso_0022 | glcB | Meso_0022 | Meso_3915 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.915 |
| Meso_0056 | Meso_1628 | Meso_0056 | Meso_1628 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.408 |
| Meso_0056 | Meso_1646 | Meso_0056 | Meso_1646 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: mlo:mlr0629 citrate synthase; Belongs to the citrate synthase family. | 0.966 |
| Meso_0056 | Meso_3357 | Meso_0056 | Meso_3357 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.701 |
| Meso_0056 | Meso_3621 | Meso_0056 | Meso_3621 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | PFAM: fumarate lyase; KEGG: cme:CMD058C fumarate hydratase precursor. | 0.966 |
| Meso_0056 | acsA | Meso_0056 | Meso_3431 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.634 |
| Meso_0056 | fumC | Meso_0056 | Meso_0355 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.966 |
| Meso_0056 | glcB | Meso_0056 | Meso_3915 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.946 |
| Meso_0056 | mdh | Meso_0056 | Meso_3395 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.992 |
| Meso_1523 | Meso_0022 | Meso_1523 | Meso_0022 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: mlo:mlr5628 probable acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.844 |
| Meso_1523 | Meso_1628 | Meso_1523 | Meso_1628 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.920 |
| Meso_1523 | Meso_1646 | Meso_1523 | Meso_1646 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: mlo:mlr0629 citrate synthase; Belongs to the citrate synthase family. | 0.937 |
| Meso_1523 | Meso_3357 | Meso_1523 | Meso_3357 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.470 |
| Meso_1523 | acsA | Meso_1523 | Meso_3431 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.922 |
| Meso_1523 | glcB | Meso_1523 | Meso_3915 | TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: nwi:Nwi_2994 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.915 |
