| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0309 | Meso_1367 | Meso_0309 | Meso_1367 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.920 |
| Meso_0309 | Meso_1729 | Meso_0309 | Meso_1729 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. | 0.822 |
| Meso_0309 | Meso_1744 | Meso_0309 | Meso_1744 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: phosphoserine phosphatase SerB HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase-like hydrolase; KEGG: mlo:mlr1449 probable phosphoserine phosphatase. | 0.907 |
| Meso_0309 | glyA | Meso_0309 | Meso_1134 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
| Meso_0309 | ilvA | Meso_0309 | Meso_1421 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
| Meso_0309 | trpA | Meso_0309 | Meso_0664 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.913 |
| Meso_0309 | trpB | Meso_0309 | Meso_0666 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.928 |
| Meso_1367 | Meso_0309 | Meso_1367 | Meso_0309 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.920 |
| Meso_1367 | Meso_1729 | Meso_1367 | Meso_1729 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. | 0.927 |
| Meso_1367 | Meso_1744 | Meso_1367 | Meso_1744 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | TIGRFAM: phosphoserine phosphatase SerB HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase-like hydrolase; KEGG: mlo:mlr1449 probable phosphoserine phosphatase. | 0.918 |
| Meso_1367 | Meso_1922 | Meso_1367 | Meso_1922 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | 0.810 |
| Meso_1367 | glyA | Meso_1367 | Meso_1134 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| Meso_1367 | ilvA | Meso_1367 | Meso_1421 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.920 |
| Meso_1367 | trpA | Meso_1367 | Meso_0664 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.915 |
| Meso_1367 | trpB | Meso_1367 | Meso_0666 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.901 |
| Meso_1424 | Meso_1729 | Meso_1424 | Meso_1729 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mlr0353 O-acetylserine (thiol) lyase. | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. | 0.995 |
| Meso_1424 | cysS | Meso_1424 | Meso_0965 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mlr0353 O-acetylserine (thiol) lyase. | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.830 |
| Meso_1424 | glyA | Meso_1424 | Meso_1134 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mlr0353 O-acetylserine (thiol) lyase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.407 |
| Meso_1729 | Meso_0309 | Meso_1729 | Meso_0309 | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.822 |
| Meso_1729 | Meso_1367 | Meso_1729 | Meso_1367 | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.927 |
