| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1747 | Meso_1748 | Meso_1747 | Meso_1748 | KEGG: bmb:BruAb1_1390 hypothetical protein. | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | 0.692 |
| Meso_1747 | Meso_1749 | Meso_1747 | Meso_1749 | KEGG: bmb:BruAb1_1390 hypothetical protein. | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | 0.692 |
| Meso_1747 | Meso_1750 | Meso_1747 | Meso_1750 | KEGG: bmb:BruAb1_1390 hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.505 |
| Meso_1747 | thyA | Meso_1747 | Meso_1751 | KEGG: bmb:BruAb1_1390 hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.501 |
| Meso_1748 | Meso_1747 | Meso_1748 | Meso_1747 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | KEGG: bmb:BruAb1_1390 hypothetical protein. | 0.692 |
| Meso_1748 | Meso_1749 | Meso_1748 | Meso_1749 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | 0.993 |
| Meso_1748 | Meso_1750 | Meso_1748 | Meso_1750 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.571 |
| Meso_1748 | Meso_2428 | Meso_1748 | Meso_2428 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit; KEGG: sil:SPO0833 formate dehydrogenase, beta subunit. | 0.733 |
| Meso_1748 | Meso_2735 | Meso_1748 | Meso_2735 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | PFAM: band 7 protein; KEGG: mlo:mlr3021 hypothetical protein. | 0.547 |
| Meso_1748 | Meso_2792 | Meso_1748 | Meso_2792 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | PFAM: cytochrome c oxidase, subunit II cytochrome c, class I; KEGG: sme:SMb21368 putative cytochrome c oxidase chain II protein. | 0.759 |
| Meso_1748 | ftsH | Meso_1748 | Meso_3167 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.893 |
| Meso_1748 | hflX | Meso_1748 | Meso_1612 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | GTP-binding protein, HSR1-related protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.590 |
| Meso_1748 | thyA | Meso_1748 | Meso_1751 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.568 |
| Meso_1748 | yidC | Meso_1748 | Meso_0376 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Protein translocase subunit yidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.563 |
| Meso_1749 | Meso_1747 | Meso_1749 | Meso_1747 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | KEGG: bmb:BruAb1_1390 hypothetical protein. | 0.692 |
| Meso_1749 | Meso_1748 | Meso_1749 | Meso_1748 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | 0.993 |
| Meso_1749 | Meso_1750 | Meso_1749 | Meso_1750 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.571 |
| Meso_1749 | Meso_2428 | Meso_1749 | Meso_2428 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit; KEGG: sil:SPO0833 formate dehydrogenase, beta subunit. | 0.733 |
| Meso_1749 | Meso_2735 | Meso_1749 | Meso_2735 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | PFAM: band 7 protein; KEGG: mlo:mlr3021 hypothetical protein. | 0.566 |
| Meso_1749 | Meso_2792 | Meso_1749 | Meso_2792 | Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. | PFAM: cytochrome c oxidase, subunit II cytochrome c, class I; KEGG: sme:SMb21368 putative cytochrome c oxidase chain II protein. | 0.759 |
