| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0675 | Meso_1498 | Meso_0675 | Meso_1498 | Mn2+-dependent serine/threonine protein kinase; KEGG: bmb:BruAb1_2096 hypothetical protein. | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | 0.454 |
| Meso_0675 | Meso_1752 | Meso_0675 | Meso_1752 | Mn2+-dependent serine/threonine protein kinase; KEGG: bmb:BruAb1_2096 hypothetical protein. | KEGG: mlo:mll1468 hypothetical protein. | 0.459 |
| Meso_1498 | Meso_0675 | Meso_1498 | Meso_0675 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | Mn2+-dependent serine/threonine protein kinase; KEGG: bmb:BruAb1_2096 hypothetical protein. | 0.454 |
| Meso_1498 | Meso_1752 | Meso_1498 | Meso_1752 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | KEGG: mlo:mll1468 hypothetical protein. | 0.460 |
| Meso_1498 | Meso_2024 | Meso_1498 | Meso_2024 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | PFAM: beta-lactamase; KEGG: ret:RHE_CH02865 putative 6-aminohexanoate-dimer hydrolase protein. | 0.406 |
| Meso_1748 | Meso_1750 | Meso_1748 | Meso_1750 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.571 |
| Meso_1748 | Meso_1752 | Meso_1748 | Meso_1752 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | KEGG: mlo:mll1468 hypothetical protein. | 0.456 |
| Meso_1748 | thyA | Meso_1748 | Meso_1751 | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.568 |
| Meso_1750 | Meso_1748 | Meso_1750 | Meso_1748 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | 0.571 |
| Meso_1750 | Meso_1752 | Meso_1750 | Meso_1752 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: mlo:mll1468 hypothetical protein. | 0.578 |
| Meso_1750 | thyA | Meso_1750 | Meso_1751 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| Meso_1752 | Meso_0675 | Meso_1752 | Meso_0675 | KEGG: mlo:mll1468 hypothetical protein. | Mn2+-dependent serine/threonine protein kinase; KEGG: bmb:BruAb1_2096 hypothetical protein. | 0.459 |
| Meso_1752 | Meso_1498 | Meso_1752 | Meso_1498 | KEGG: mlo:mll1468 hypothetical protein. | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | 0.460 |
| Meso_1752 | Meso_1748 | Meso_1752 | Meso_1748 | KEGG: mlo:mll1468 hypothetical protein. | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | 0.456 |
| Meso_1752 | Meso_1750 | Meso_1752 | Meso_1750 | KEGG: mlo:mll1468 hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.578 |
| Meso_1752 | Meso_2024 | Meso_1752 | Meso_2024 | KEGG: mlo:mll1468 hypothetical protein. | PFAM: beta-lactamase; KEGG: ret:RHE_CH02865 putative 6-aminohexanoate-dimer hydrolase protein. | 0.425 |
| Meso_1752 | thyA | Meso_1752 | Meso_1751 | KEGG: mlo:mll1468 hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.615 |
| Meso_2024 | Meso_1498 | Meso_2024 | Meso_1498 | PFAM: beta-lactamase; KEGG: ret:RHE_CH02865 putative 6-aminohexanoate-dimer hydrolase protein. | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bmb:BruAb1_1372 hypothetical protein. | 0.406 |
| Meso_2024 | Meso_1752 | Meso_2024 | Meso_1752 | PFAM: beta-lactamase; KEGG: ret:RHE_CH02865 putative 6-aminohexanoate-dimer hydrolase protein. | KEGG: mlo:mll1468 hypothetical protein. | 0.425 |
| thyA | Meso_1748 | Meso_1751 | Meso_1748 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Protease FtsH subunit HflC; HflC and HflK could regulate a protease. | 0.568 |
