| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1129 | hemC | Meso_1129 | Meso_3202 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
| Meso_1129 | hemE | Meso_1129 | Meso_3476 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.803 |
| Meso_1129 | hemF | Meso_1129 | Meso_2169 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.605 |
| Meso_1129 | hemH | Meso_1129 | Meso_2724 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.595 |
| Meso_2170 | hemF | Meso_2170 | Meso_2169 | KEGG: mlo:mll2721 hypothetical protein. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.674 |
| Meso_3239 | hemF | Meso_3239 | Meso_2169 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding FAD dependent oxidoreductase; KEGG: mlo:mlr4251 2-octaprenyl-6-methoxyphenol 4-monoxygenase, ubiH. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.444 |
| Meso_3475 | hemE | Meso_3475 | Meso_3476 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.921 |
| Meso_3475 | hemF | Meso_3475 | Meso_2169 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.951 |
| Meso_3475 | hemH | Meso_3475 | Meso_2724 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.954 |
| ctaB | hemF | Meso_0743 | Meso_2169 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.460 |
| ctaB | hemH | Meso_0743 | Meso_2724 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.927 |
| hemC | Meso_1129 | Meso_3202 | Meso_1129 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.996 |
| hemC | hemE | Meso_3202 | Meso_3476 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.985 |
| hemC | hemF | Meso_3202 | Meso_2169 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.604 |
| hemC | hemH | Meso_3202 | Meso_2724 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.587 |
| hemE | Meso_1129 | Meso_3476 | Meso_1129 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.803 |
| hemE | Meso_3475 | Meso_3476 | Meso_3475 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | 0.921 |
| hemE | hemC | Meso_3476 | Meso_3202 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.985 |
| hemE | hemF | Meso_3476 | Meso_2169 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.968 |
| hemE | hemH | Meso_3476 | Meso_2724 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.911 |
