| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0969 | Meso_1488 | Meso_0969 | Meso_1488 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | 0.908 |
| Meso_0969 | Meso_3241 | Meso_0969 | Meso_3241 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: sth:STH1827 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.916 |
| Meso_0969 | ilvC | Meso_0969 | Meso_1496 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.601 |
| Meso_0969 | ilvD | Meso_0969 | Meso_1688 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.942 |
| Meso_0969 | ilvD-2 | Meso_0969 | Meso_2666 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.943 |
| Meso_0969 | ilvE | Meso_0969 | Meso_2140 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.969 |
| Meso_0969 | leuA | Meso_0969 | Meso_2190 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.900 |
| Meso_0969 | leuB | Meso_0969 | Meso_3381 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.860 |
| Meso_0969 | leuC | Meso_0969 | Meso_3448 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.983 |
| Meso_1488 | Meso_0969 | Meso_1488 | Meso_0969 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.908 |
| Meso_1488 | ilvC | Meso_1488 | Meso_1496 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.988 |
| Meso_1488 | ilvD | Meso_1488 | Meso_1688 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.868 |
| Meso_1488 | ilvD-2 | Meso_1488 | Meso_2666 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.810 |
| Meso_1488 | leuA | Meso_1488 | Meso_2190 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.873 |
| Meso_1488 | leuB | Meso_1488 | Meso_3381 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.979 |
| Meso_1488 | leuC | Meso_1488 | Meso_3448 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: mlo:mll1433 acetolactate synthase large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.729 |
| Meso_3241 | Meso_0969 | Meso_3241 | Meso_0969 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: sth:STH1827 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase LeuA allosteric (dimerisation) domain; KEGG: mlo:mlr7805 homocitrate synthase nifV candidate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.916 |
| Meso_3241 | ilvD | Meso_3241 | Meso_1688 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: sth:STH1827 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mll1102 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.918 |
| Meso_3241 | ilvD-2 | Meso_3241 | Meso_2666 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: sth:STH1827 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mlo:mlr5361 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.918 |
| Meso_3241 | ilvE | Meso_3241 | Meso_2140 | PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: sth:STH1827 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.919 |
