| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_1167 | Meso_0328 | Meso_1167 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | 0.961 |
| Meso_0328 | Meso_2028 | Meso_0328 | Meso_2028 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.994 |
| Meso_0328 | Meso_2698 | Meso_0328 | Meso_2698 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.763 |
| Meso_0328 | Meso_2744 | Meso_0328 | Meso_2744 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.444 |
| Meso_0328 | Meso_3924 | Meso_0328 | Meso_3924 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.959 |
| Meso_0328 | ahcY | Meso_0328 | Meso_3576 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.960 |
| Meso_0328 | cysN | Meso_0328 | Meso_0834 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.623 |
| Meso_0328 | fhs | Meso_0328 | Meso_2204 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.961 |
| Meso_0328 | metAA | Meso_0328 | Meso_3083 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.864 |
| Meso_1167 | Meso_0328 | Meso_1167 | Meso_0328 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |
| Meso_1167 | Meso_2698 | Meso_1167 | Meso_2698 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.614 |
| Meso_1167 | Meso_3924 | Meso_1167 | Meso_3924 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.921 |
| Meso_1167 | ahcY | Meso_1167 | Meso_3576 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.916 |
| Meso_1167 | cysN | Meso_1167 | Meso_0834 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.665 |
| Meso_1167 | metAA | Meso_1167 | Meso_3083 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.966 |
| Meso_2028 | Meso_0328 | Meso_2028 | Meso_0328 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.994 |
| Meso_2028 | Meso_2698 | Meso_2028 | Meso_2698 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.744 |
| Meso_2028 | Meso_2744 | Meso_2028 | Meso_2744 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.606 |
| Meso_2028 | Meso_3924 | Meso_2028 | Meso_3924 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.781 |
| Meso_2028 | ahcY | Meso_2028 | Meso_3576 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.455 |
