| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0975 | hemH | Meso_0975 | Meso_2724 | PFAM: ABC transporter, transmembrane region ABC transporter related; SMART: ATPase; KEGG: bms:BR0442 ABC transporter, ATP-binding/permease protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.700 |
| Meso_1129 | Meso_3989 | Meso_1129 | Meso_3989 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.904 |
| Meso_1129 | hemE | Meso_1129 | Meso_3476 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.803 |
| Meso_1129 | hemF | Meso_1129 | Meso_2169 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.605 |
| Meso_1129 | hemH | Meso_1129 | Meso_2724 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.595 |
| Meso_2207 | Meso_4048 | Meso_2207 | Meso_4048 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mlo:mlr2805 hypothetical protein. | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | 0.900 |
| Meso_2207 | ctaB | Meso_2207 | Meso_0743 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mlo:mlr2805 hypothetical protein. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 0.900 |
| Meso_2207 | hemH | Meso_2207 | Meso_2724 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mlo:mlr2805 hypothetical protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.908 |
| Meso_3243 | ctaB | Meso_3243 | Meso_0743 | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: mlo:mll4260 succinate dehydrogenase iron-sulfur protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 0.431 |
| Meso_3243 | hemH | Meso_3243 | Meso_2724 | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: mlo:mll4260 succinate dehydrogenase iron-sulfur protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.667 |
| Meso_3475 | hemE | Meso_3475 | Meso_3476 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.921 |
| Meso_3475 | hemF | Meso_3475 | Meso_2169 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.951 |
| Meso_3475 | hemH | Meso_3475 | Meso_2724 | PFAM: conserved hypothetical protein 701; KEGG: bmb:BruAb1_2040 hypothetical membrane protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.954 |
| Meso_3989 | Meso_1129 | Meso_3989 | Meso_1129 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.904 |
| Meso_3989 | hemE | Meso_3989 | Meso_3476 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.958 |
| Meso_3989 | hemH | Meso_3989 | Meso_2724 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.606 |
| Meso_4048 | Meso_2207 | Meso_4048 | Meso_2207 | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mlo:mlr2805 hypothetical protein. | 0.900 |
| Meso_4048 | hemH | Meso_4048 | Meso_2724 | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.916 |
| ctaB | Meso_2207 | Meso_0743 | Meso_2207 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: mlo:mlr2805 hypothetical protein. | 0.900 |
| ctaB | Meso_3243 | Meso_0743 | Meso_3243 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: mlo:mll4260 succinate dehydrogenase iron-sulfur protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.431 |
