| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0088 | Meso_0592 | Meso_0088 | Meso_0592 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | 0.900 |
| Meso_0088 | Meso_0593 | Meso_0088 | Meso_0593 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | 0.941 |
| Meso_0088 | Meso_2745 | Meso_0088 | Meso_2745 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.911 |
| Meso_0088 | gcvP | Meso_0088 | Meso_1016 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.943 |
| Meso_0088 | glyA | Meso_0088 | Meso_1134 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
| Meso_0088 | kbl | Meso_0088 | Meso_0443 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.917 |
| Meso_0088 | tdh | Meso_0088 | Meso_0444 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.653 |
| Meso_0309 | Meso_0760 | Meso_0309 | Meso_0760 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.937 |
| Meso_0309 | Meso_2745 | Meso_0309 | Meso_2745 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.913 |
| Meso_0309 | gcvP | Meso_0309 | Meso_1016 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.417 |
| Meso_0309 | glyA | Meso_0309 | Meso_1134 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
| Meso_0309 | ilvA | Meso_0309 | Meso_1421 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
| Meso_0309 | tdh | Meso_0309 | Meso_0444 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.906 |
| Meso_0592 | Meso_0088 | Meso_0592 | Meso_0088 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 0.900 |
| Meso_0592 | Meso_0593 | Meso_0592 | Meso_0593 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | 0.999 |
| Meso_0592 | Meso_2745 | Meso_0592 | Meso_2745 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.905 |
| Meso_0592 | gcvP | Meso_0592 | Meso_1016 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.906 |
| Meso_0592 | glyA | Meso_0592 | Meso_1134 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
| Meso_0592 | kbl | Meso_0592 | Meso_0443 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.900 |
| Meso_0593 | Meso_0088 | Meso_0593 | Meso_0088 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 0.941 |
