| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0428 | Meso_3418 | Meso_0428 | Meso_3418 | TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 pseudouridine synthase; KEGG: mlo:mlr8253 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.512 |
| Meso_0428 | efp | Meso_0428 | Meso_3184 | TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 pseudouridine synthase; KEGG: mlo:mlr8253 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.474 |
| Meso_0428 | rlmN | Meso_0428 | Meso_2859 | TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 pseudouridine synthase; KEGG: mlo:mlr8253 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.487 |
| Meso_0464 | rlmN | Meso_0464 | Meso_2859 | PFAM: Fmu (Sun); KEGG: mlo:mlr6944 SUN-family protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.695 |
| Meso_1136 | Meso_3418 | Meso_1136 | Meso_3418 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.675 |
| Meso_1136 | rlmN | Meso_1136 | Meso_2859 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.606 |
| Meso_3208 | Meso_3418 | Meso_3208 | Meso_3418 | Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.421 |
| Meso_3208 | Meso_4013 | Meso_3208 | Meso_4013 | Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.468 |
| Meso_3208 | rlmN | Meso_3208 | Meso_2859 | Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.598 |
| Meso_3390 | Meso_3418 | Meso_3390 | Meso_3418 | MiaB-like tRNA modifying enzyme; KEGG: mlo:mlr4319 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM protein of unknown function UPF0004 Radical SAM; SMART: Elongator protein 3/MiaB/NifB. | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.641 |
| Meso_3390 | Meso_4013 | Meso_3390 | Meso_4013 | MiaB-like tRNA modifying enzyme; KEGG: mlo:mlr4319 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM protein of unknown function UPF0004 Radical SAM; SMART: Elongator protein 3/MiaB/NifB. | Coproporphyrinogen III oxidase, anaerobic; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.535 |
| Meso_3390 | rlmN | Meso_3390 | Meso_2859 | MiaB-like tRNA modifying enzyme; KEGG: mlo:mlr4319 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM protein of unknown function UPF0004 Radical SAM; SMART: Elongator protein 3/MiaB/NifB. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.647 |
| Meso_3418 | Meso_0428 | Meso_3418 | Meso_0428 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 pseudouridine synthase; KEGG: mlo:mlr8253 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.512 |
| Meso_3418 | Meso_1136 | Meso_3418 | Meso_1136 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.675 |
| Meso_3418 | Meso_3208 | Meso_3418 | Meso_3208 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.421 |
| Meso_3418 | Meso_3390 | Meso_3418 | Meso_3390 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | MiaB-like tRNA modifying enzyme; KEGG: mlo:mlr4319 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM protein of unknown function UPF0004 Radical SAM; SMART: Elongator protein 3/MiaB/NifB. | 0.641 |
| Meso_3418 | efp | Meso_3418 | Meso_3184 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.465 |
| Meso_3418 | miaB | Meso_3418 | Meso_3919 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.641 |
| Meso_3418 | rlmN | Meso_3418 | Meso_2859 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.921 |
| Meso_3418 | tgt | Meso_3418 | Meso_1406 | PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.524 |
