| node1 | node2 | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_0856 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: methylmalonyl-CoA mutase, large subunit Methylmalonyl-CoA mutase-like; PFAM: methylmalonyl-CoA mutase cobalamin B12-binding; KEGG: mlo:mll7619 methylmalonyl-CoA large subunit. | 0.540 |
| Meso_0328 | Meso_3031 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.635 |
| Meso_0328 | Meso_3989 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.657 |
| Meso_0856 | Meso_0328 | TIGRFAM: methylmalonyl-CoA mutase, large subunit Methylmalonyl-CoA mutase-like; PFAM: methylmalonyl-CoA mutase cobalamin B12-binding; KEGG: mlo:mll7619 methylmalonyl-CoA large subunit. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.540 |
| Meso_0856 | Meso_3031 | TIGRFAM: methylmalonyl-CoA mutase, large subunit Methylmalonyl-CoA mutase-like; PFAM: methylmalonyl-CoA mutase cobalamin B12-binding; KEGG: mlo:mll7619 methylmalonyl-CoA large subunit. | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.649 |
| Meso_1289 | Meso_3031 | PFAM: flavin reductase-like, FMN-binding; KEGG: mlo:mlr0087 putative 4-hydroxyphenylacetate 3-monooxygenase. | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.900 |
| Meso_1289 | Meso_3069 | PFAM: flavin reductase-like, FMN-binding; KEGG: mlo:mlr0087 putative 4-hydroxyphenylacetate 3-monooxygenase. | TIGRFAM: cobalt chelatase, pCobS small subunit; PFAM: ATPase associated with various cellular activities, AAA_5; KEGG: bme:BMEI0049 CobS protein. | 0.900 |
| Meso_1289 | Meso_3071 | PFAM: flavin reductase-like, FMN-binding; KEGG: mlo:mlr0087 putative 4-hydroxyphenylacetate 3-monooxygenase. | Cobaltochelatase CobT subunit; KEGG: mlo:mll3561 CobT protein; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase, CobT subunit; SMART: von Willebrand factor, type A. | 0.900 |
| Meso_3028 | Meso_3029 | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.590 |
| Meso_3028 | Meso_3030 | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | KEGG: ret:RHE_CH03789 hypothetical protein. | 0.542 |
| Meso_3028 | Meso_3031 | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.540 |
| Meso_3028 | Meso_3032 | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | PFAM: Rhomboid-like protein; KEGG: atc:AGR_L_2465 hypothetical protein. | 0.452 |
| Meso_3029 | Meso_3028 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | 0.590 |
| Meso_3029 | Meso_3030 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | KEGG: ret:RHE_CH03789 hypothetical protein. | 0.718 |
| Meso_3029 | Meso_3031 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.698 |
| Meso_3029 | Meso_3032 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | PFAM: Rhomboid-like protein; KEGG: atc:AGR_L_2465 hypothetical protein. | 0.580 |
| Meso_3030 | Meso_3028 | KEGG: ret:RHE_CH03789 hypothetical protein. | TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN; KEGG: mlo:mll3481 contains similarity to transporter (YfkH). | 0.542 |
| Meso_3030 | Meso_3029 | KEGG: ret:RHE_CH03789 hypothetical protein. | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR; KEGG: mlo:mlr3482 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.718 |
| Meso_3030 | Meso_3031 | KEGG: ret:RHE_CH03789 hypothetical protein. | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: mlo:mlr3485 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.781 |
| Meso_3030 | Meso_3032 | KEGG: ret:RHE_CH03789 hypothetical protein. | PFAM: Rhomboid-like protein; KEGG: atc:AGR_L_2465 hypothetical protein. | 0.669 |