| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1129 | Meso_2580 | Meso_1129 | Meso_2580 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.857 |
| Meso_1129 | Meso_3201 | Meso_1129 | Meso_3201 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.831 |
| Meso_1129 | Meso_3989 | Meso_1129 | Meso_3989 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.904 |
| Meso_1129 | hemC | Meso_1129 | Meso_3202 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
| Meso_1129 | hemE | Meso_1129 | Meso_3476 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.803 |
| Meso_1129 | hemF | Meso_1129 | Meso_2169 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.605 |
| Meso_2580 | Meso_1129 | Meso_2580 | Meso_1129 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.857 |
| Meso_2580 | Meso_3201 | Meso_2580 | Meso_3201 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.498 |
| Meso_2580 | Meso_3989 | Meso_2580 | Meso_3989 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.606 |
| Meso_2580 | hemC | Meso_2580 | Meso_3202 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.761 |
| Meso_2580 | hemE | Meso_2580 | Meso_3476 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.581 |
| Meso_3199 | Meso_3200 | Meso_3199 | Meso_3200 | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | KEGG: mlo:mll4219 putative phage tail protein. | 0.933 |
| Meso_3199 | Meso_3201 | Meso_3199 | Meso_3201 | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.691 |
| Meso_3199 | gpsA | Meso_3199 | Meso_3204 | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | PFAM: UBA/THIF-type NAD/FAD binding fold NADP oxidoreductase, coenzyme F420-dependent NAD-dependent glycerol-3-phosphate dehydrogenase-like Ketopantoate reductase ApbA/PanE-like; KEGG: mlo:mlr4225 glycerol-3-phosphate dehydrogenase. | 0.507 |
| Meso_3199 | hemC | Meso_3199 | Meso_3202 | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.679 |
| Meso_3199 | tsaD | Meso_3199 | Meso_3203 | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.607 |
| Meso_3200 | Meso_3199 | Meso_3200 | Meso_3199 | KEGG: mlo:mll4219 putative phage tail protein. | PFAM: HemY-like Tetratricopeptide TPR_2; KEGG: mlo:mll4218 weak similarity to E. coli HemY protein. | 0.933 |
| Meso_3200 | Meso_3201 | Meso_3200 | Meso_3201 | KEGG: mlo:mll4219 putative phage tail protein. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.661 |
| Meso_3200 | gpsA | Meso_3200 | Meso_3204 | KEGG: mlo:mll4219 putative phage tail protein. | PFAM: UBA/THIF-type NAD/FAD binding fold NADP oxidoreductase, coenzyme F420-dependent NAD-dependent glycerol-3-phosphate dehydrogenase-like Ketopantoate reductase ApbA/PanE-like; KEGG: mlo:mlr4225 glycerol-3-phosphate dehydrogenase. | 0.490 |
| Meso_3200 | hemC | Meso_3200 | Meso_3202 | KEGG: mlo:mll4219 putative phage tail protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.615 |
