Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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htpXHeat shock protein. Metallo peptidase. MEROPS family M48B; PFAM: peptidase M48, Ste24p; KEGG: sme:SMc04091 putative protease transmembrane protein; Belongs to the peptidase M48B family. (313 aa)    
Predicted Functional Partners:
Meso_3418
PFAM: Fmu (Sun) NusB/RsmB/TIM44; KEGG: mlo:mlr4098 hypothetical protein, similarity to RNA-binding Sun protein, putative Fmu protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
       0.838
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 0.832
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
 
 0.729
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.692
Meso_2723
PFAM: protein of unknown function DUF533; KEGG: mlo:mll2991 hypothetical protein.
   
    0.632
Meso_3272
TIGRFAM: thioredoxin; PFAM: Tetratricopeptide TPR_4 Thioredoxin domain; KEGG: mlo:mll4432 thioredoxin.
  
  
 0.614
Meso_3416
PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein.
       0.613
Meso_3419
PFAM: Heparinase II/III-like; KEGG: mlo:mlr4100 hypothetical protein.
       0.605
clpB
ATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
  
 0.582
Meso_3484
PFAM: FxsA cytoplasmic membrane protein; KEGG: bmb:BruAb1_2048 BfxsA protein, hypothetical.
   
  
 0.579
Your Current Organism:
Chelativorans sp. BNC1
NCBI taxonomy Id: 266779
Other names: C. sp. BNC1, Mesorhizobium sp. BNC1
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