| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1285 | glyA | Meso_1285 | Meso_1134 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.709 |
| Meso_1285 | guaB | Meso_1285 | Meso_0467 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.782 |
| Meso_1285 | purA | Meso_1285 | Meso_3159 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.992 |
| Meso_1285 | purC | Meso_1285 | Meso_1281 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mlo:mll0069 phosphoribosylaminoimidazole-succinocarboxamide synthase. | 0.998 |
| Meso_1285 | purD | Meso_1285 | Meso_0719 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; KEGG: mlo:mlr7447 phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.962 |
| Meso_1285 | purF | Meso_1285 | Meso_0983 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.970 |
| Meso_1285 | purH | Meso_1285 | Meso_3420 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.982 |
| Meso_1285 | purM | Meso_1285 | Meso_1966 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like; KEGG: mlo:mll7962 5'-phosphoribosyl-5-aminoimidazole synthetase. | 0.960 |
| Meso_1285 | purN | Meso_1285 | Meso_1967 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.811 |
| fhs | glyA | Meso_2204 | Meso_1134 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
| fhs | purC | Meso_2204 | Meso_1281 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mlo:mll0069 phosphoribosylaminoimidazole-succinocarboxamide synthase. | 0.774 |
| fhs | purD | Meso_2204 | Meso_0719 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; KEGG: mlo:mlr7447 phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.684 |
| fhs | purF | Meso_2204 | Meso_0983 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.736 |
| fhs | purH | Meso_2204 | Meso_3420 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.980 |
| fhs | purM | Meso_2204 | Meso_1966 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like; KEGG: mlo:mll7962 5'-phosphoribosyl-5-aminoimidazole synthetase. | 0.441 |
| fhs | purN | Meso_2204 | Meso_1967 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.977 |
| glyA | Meso_1285 | Meso_1134 | Meso_1285 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.709 |
| glyA | fhs | Meso_1134 | Meso_2204 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.983 |
| glyA | guaB | Meso_1134 | Meso_0467 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.704 |
| glyA | purA | Meso_1134 | Meso_3159 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.783 |
