| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_1611 | Meso_4055 | Meso_1611 | Meso_4055 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.900 |
| Meso_1611 | coaA | Meso_1611 | Meso_3499 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | 0.900 |
| Meso_3494 | coaA | Meso_3494 | Meso_3499 | KEGG: mlo:mlr5010 hypothetical protein. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | 0.865 |
| Meso_3494 | hisA | Meso_3494 | Meso_3496 | KEGG: mlo:mlr5010 hypothetical protein. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | 0.838 |
| Meso_3494 | hisB | Meso_3494 | Meso_3493 | KEGG: mlo:mlr5010 hypothetical protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mlo:mlr5008 imidazoleglycerol-phosphate dehydratase. | 0.838 |
| Meso_3494 | hisE | Meso_3494 | Meso_3498 | KEGG: mlo:mlr5010 hypothetical protein. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mlo:mlr5018 phosphoribosyl-ATP pyrophosphatase. | 0.838 |
| Meso_3494 | hisF | Meso_3494 | Meso_3497 | KEGG: mlo:mlr5010 hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.838 |
| Meso_3494 | hisH | Meso_3494 | Meso_3495 | KEGG: mlo:mlr5010 hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.838 |
| Meso_4055 | Meso_1611 | Meso_4055 | Meso_1611 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. | 0.900 |
| Meso_4055 | coaA | Meso_4055 | Meso_3499 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | 0.936 |
| Meso_4055 | coaD | Meso_4055 | Meso_1402 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.957 |
| Meso_4055 | panC | Meso_4055 | Meso_2560 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.897 |
| coaA | Meso_1611 | Meso_3499 | Meso_1611 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. | 0.900 |
| coaA | Meso_3494 | Meso_3499 | Meso_3494 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | KEGG: mlo:mlr5010 hypothetical protein. | 0.865 |
| coaA | Meso_4055 | Meso_3499 | Meso_4055 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.936 |
| coaA | coaD | Meso_3499 | Meso_1402 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.940 |
| coaA | hisA | Meso_3499 | Meso_3496 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. | 0.838 |
| coaA | hisB | Meso_3499 | Meso_3493 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mlo:mlr5008 imidazoleglycerol-phosphate dehydratase. | 0.838 |
| coaA | hisE | Meso_3499 | Meso_3498 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mlo:mlr5018 phosphoribosyl-ATP pyrophosphatase. | 0.806 |
| coaA | hisF | Meso_3499 | Meso_3497 | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.838 |
