| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_0494 | Meso_0328 | Meso_0494 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: mlo:mlr6947 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. | 0.467 |
| Meso_0328 | Meso_1112 | Meso_0328 | Meso_1112 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | 0.964 |
| Meso_0328 | Meso_1167 | Meso_0328 | Meso_1167 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | 0.961 |
| Meso_0328 | Meso_2364 | Meso_0328 | Meso_2364 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: rru:Rru_A1613 cystathionine beta-lyase. | 0.964 |
| Meso_0328 | Meso_2643 | Meso_0328 | Meso_2643 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: aminotransferase, class I and II Thioredoxin domain; KEGG: bcl:ABC2888 aminotransferase. | 0.948 |
| Meso_0328 | Meso_3629 | Meso_0328 | Meso_3629 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mag:amb1294 cystathionine beta-lyase/cystathionine gamma-synthase. | 0.964 |
| Meso_0328 | ahcY | Meso_0328 | Meso_3576 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.960 |
| Meso_0328 | metE | Meso_0328 | Meso_2701 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.975 |
| Meso_0328 | metZ | Meso_0328 | Meso_0098 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.965 |
| Meso_0494 | Meso_0328 | Meso_0494 | Meso_0328 | KEGG: mlo:mlr6947 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.467 |
| Meso_0494 | Meso_2404 | Meso_0494 | Meso_2404 | KEGG: mlo:mlr6947 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. | PFAM: amidohydrolase Amidohydrolase 3; KEGG: sth:STH1703 putative N-ethylammeline chlorohydrolase. | 0.907 |
| Meso_0494 | ahcY | Meso_0494 | Meso_3576 | KEGG: mlo:mlr6947 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.915 |
| Meso_1112 | Meso_0328 | Meso_1112 | Meso_0328 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.964 |
| Meso_1112 | Meso_1167 | Meso_1112 | Meso_1167 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | 0.937 |
| Meso_1112 | Meso_2364 | Meso_1112 | Meso_2364 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: rru:Rru_A1613 cystathionine beta-lyase. | 0.906 |
| Meso_1112 | Meso_2643 | Meso_1112 | Meso_2643 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | PFAM: aminotransferase, class I and II Thioredoxin domain; KEGG: bcl:ABC2888 aminotransferase. | 0.929 |
| Meso_1112 | Meso_3629 | Meso_1112 | Meso_3629 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mag:amb1294 cystathionine beta-lyase/cystathionine gamma-synthase. | 0.905 |
| Meso_1112 | ahcY | Meso_1112 | Meso_3576 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.916 |
| Meso_1112 | metE | Meso_1112 | Meso_2701 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.932 |
| Meso_1112 | metZ | Meso_1112 | Meso_0098 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.920 |
