node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Meso_3659 | Meso_3661 | Meso_3659 | Meso_3661 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase Amidohydrolase 3; KEGG: mlo:mll4974 hypothetical protein. | 0.718 |
Meso_3659 | Meso_3662 | Meso_3659 | Meso_3662 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | PFAM: protein of unknown function DUF1045; KEGG: mlo:mll4975 contains weak similarity to xylose isomerase. | 0.752 |
Meso_3659 | phnN | Meso_3659 | Meso_3660 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). | 0.718 |
Meso_3661 | Meso_3659 | Meso_3661 | Meso_3659 | TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase Amidohydrolase 3; KEGG: mlo:mll4974 hypothetical protein. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | 0.718 |
Meso_3661 | Meso_3662 | Meso_3661 | Meso_3662 | TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase Amidohydrolase 3; KEGG: mlo:mll4974 hypothetical protein. | PFAM: protein of unknown function DUF1045; KEGG: mlo:mll4975 contains weak similarity to xylose isomerase. | 0.953 |
Meso_3661 | phnN | Meso_3661 | Meso_3660 | TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase Amidohydrolase 3; KEGG: mlo:mll4974 hypothetical protein. | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). | 0.972 |
Meso_3662 | Meso_3659 | Meso_3662 | Meso_3659 | PFAM: protein of unknown function DUF1045; KEGG: mlo:mll4975 contains weak similarity to xylose isomerase. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | 0.752 |
Meso_3662 | Meso_3661 | Meso_3662 | Meso_3661 | PFAM: protein of unknown function DUF1045; KEGG: mlo:mll4975 contains weak similarity to xylose isomerase. | TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase Amidohydrolase 3; KEGG: mlo:mll4974 hypothetical protein. | 0.953 |
Meso_3662 | phnN | Meso_3662 | Meso_3660 | PFAM: protein of unknown function DUF1045; KEGG: mlo:mll4975 contains weak similarity to xylose isomerase. | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). | 0.986 |
Meso_3877 | Meso_3880 | Meso_3877 | Meso_3880 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3 Pyrimidine nucleoside phosphorylase-like; KEGG: hch:HCH_01516 thymidine phosphorylase. | 0.917 |
Meso_3877 | hisG | Meso_3877 | Meso_0419 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.845 |
Meso_3877 | hisZ | Meso_3877 | Meso_0420 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.819 |
Meso_3877 | phnN | Meso_3877 | Meso_3660 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). | 0.900 |
Meso_3877 | prs | Meso_3877 | Meso_2155 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.918 |
Meso_3877 | purF | Meso_3877 | Meso_0983 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.925 |
Meso_3877 | pyrE | Meso_3877 | Meso_1476 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.839 |
Meso_3880 | Meso_3877 | Meso_3880 | Meso_3877 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3 Pyrimidine nucleoside phosphorylase-like; KEGG: hch:HCH_01516 thymidine phosphorylase. | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | 0.917 |
Meso_3880 | phnN | Meso_3880 | Meso_3660 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3 Pyrimidine nucleoside phosphorylase-like; KEGG: hch:HCH_01516 thymidine phosphorylase. | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). | 0.779 |
hisG | Meso_3877 | Meso_0419 | Meso_3877 | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. | 0.845 |
hisG | hisZ | Meso_0419 | Meso_0420 | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.999 |