| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_1167 | Meso_0328 | Meso_1167 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | 0.961 |
| Meso_0328 | Meso_2028 | Meso_0328 | Meso_2028 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.994 |
| Meso_0328 | Meso_2698 | Meso_0328 | Meso_2698 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.763 |
| Meso_0328 | Meso_3924 | Meso_0328 | Meso_3924 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.959 |
| Meso_0328 | ahcY | Meso_0328 | Meso_3576 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.960 |
| Meso_0328 | glyA | Meso_0328 | Meso_1134 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
| Meso_0328 | metE | Meso_0328 | Meso_2701 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.975 |
| Meso_1167 | Meso_0328 | Meso_1167 | Meso_0328 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |
| Meso_1167 | Meso_2698 | Meso_1167 | Meso_2698 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.614 |
| Meso_1167 | Meso_3924 | Meso_1167 | Meso_3924 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.921 |
| Meso_1167 | ahcY | Meso_1167 | Meso_3576 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.916 |
| Meso_1167 | metE | Meso_1167 | Meso_2701 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.922 |
| Meso_2028 | Meso_0328 | Meso_2028 | Meso_0328 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.994 |
| Meso_2028 | Meso_2698 | Meso_2028 | Meso_2698 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. | 0.744 |
| Meso_2028 | Meso_3924 | Meso_2028 | Meso_3924 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.781 |
| Meso_2028 | ahcY | Meso_2028 | Meso_3576 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.455 |
| Meso_2028 | glyA | Meso_2028 | Meso_1134 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
| Meso_2028 | metE | Meso_2028 | Meso_2701 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.835 |
| Meso_2199 | Meso_3924 | Meso_2199 | Meso_3924 | TIGRFAM: glutamine amidotransferase of anthranilate synthase anthranilate synthase; PFAM: glutamine amidotransferase class-I Anthranilate synthase component I and chorismate binding protein Anthranilate synthase component I-like; KEGG: mlo:mlr2774 anthranilate synthase. | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. | 0.850 |
| Meso_2199 | glyA | Meso_2199 | Meso_1134 | TIGRFAM: glutamine amidotransferase of anthranilate synthase anthranilate synthase; PFAM: glutamine amidotransferase class-I Anthranilate synthase component I and chorismate binding protein Anthranilate synthase component I-like; KEGG: mlo:mlr2774 anthranilate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.593 |
