| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_2575 | Meso_4052 | Meso_2575 | Meso_4052 | Transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding regulatory protein, Crp; KEGG: rsp:RSP_3616 transcriptional regulator, Crp-Fnr family. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | 0.425 |
| Meso_4052 | Meso_2575 | Meso_4052 | Meso_2575 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | Transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding regulatory protein, Crp; KEGG: rsp:RSP_3616 transcriptional regulator, Crp-Fnr family. | 0.425 |
| Meso_4052 | ahcY | Meso_4052 | Meso_3576 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.539 |
| Meso_4052 | cysS | Meso_4052 | Meso_0965 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.564 |
| Meso_4052 | folE | Meso_4052 | Meso_1004 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | PFAM: GTP cyclohydrolase I; KEGG: mlo:mlr0922 GTP cyclohydrolase I. | 0.968 |
| Meso_4052 | guaA | Meso_4052 | Meso_0495 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.453 |
| Meso_4052 | queC | Meso_4052 | Meso_4053 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.998 |
| Meso_4052 | queE | Meso_4052 | Meso_4051 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | preQ(0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
| Meso_4052 | queF | Meso_4052 | Meso_0442 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.932 |
| Meso_4052 | ribB | Meso_4052 | Meso_0731 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.431 |
| Meso_4052 | tgt | Meso_4052 | Meso_1406 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.405 |
| ahcY | Meso_4052 | Meso_3576 | Meso_4052 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | 0.539 |
| ahcY | guaA | Meso_3576 | Meso_0495 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.449 |
| cysS | Meso_4052 | Meso_0965 | Meso_4052 | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | 0.564 |
| cysS | guaA | Meso_0965 | Meso_0495 | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.578 |
| cysS | ribB | Meso_0965 | Meso_0731 | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.424 |
| folE | Meso_4052 | Meso_1004 | Meso_4052 | PFAM: GTP cyclohydrolase I; KEGG: mlo:mlr0922 GTP cyclohydrolase I. | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. | 0.968 |
| folE | guaA | Meso_1004 | Meso_0495 | PFAM: GTP cyclohydrolase I; KEGG: mlo:mlr0922 GTP cyclohydrolase I. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.436 |
| folE | queC | Meso_1004 | Meso_4053 | PFAM: GTP cyclohydrolase I; KEGG: mlo:mlr0922 GTP cyclohydrolase I. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.441 |
| folE | queE | Meso_1004 | Meso_4051 | PFAM: GTP cyclohydrolase I; KEGG: mlo:mlr0922 GTP cyclohydrolase I. | preQ(0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.573 |
