STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Krad_0738Putative transcriptional regulator, MerR family; PFAM: regulatory protein MerR; KEGG: sma:SAV1214 transcriptional regulator. (356 aa)    
Predicted Functional Partners:
whiB-3
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
 
     0.632
Krad_0310
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein.
  
 
   0.554
Krad_0739
PFAM: regulatory protein LuxR; response regulator receiver; KEGG: sma:SAV4998 two-component system response regulator.
       0.498
Krad_1556
KEGG: lxx:Lxx10400 membrane protein.
  
     0.449
Krad_3848
PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; KEGG: nfa:nfa49650 putative histidine kinase.
  
 
   0.449
Krad_4122
PFAM: ATP-binding region ATPase domain protein; Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: sma:SAV3185 magnesium or manganese-dependent protein phosphatase.
  
    0.447
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.434
Krad_4231
PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein; KEGG: art:Arth_3806 chaperone DnaJ domain protein.
  
 
 0.434
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
       0.431
Krad_1809
KEGG: rha:RHA1_ro10086 hypothetical protein.
  
     0.420
Your Current Organism:
Kineococcus radiotolerans
NCBI taxonomy Id: 266940
Other names: K. radiotolerans SRS30216 = ATCC BAA-149, Kineococcus radiotolerans ATCC BAA-149, Kineococcus radiotolerans ATCC BAA-149 = SRS30216, Kineococcus radiotolerans SRS30216, Kineococcus radiotolerans SRS30216 = ATCC BAA-149, Kineococcus-like str. SRS30216
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