STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (418 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 0.997
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
  
 0.994
Krad_3391
TIGRFAM: para-aminobenzoate synthase, subunit I; glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: sma:SAV1178 putative para-aminobenzoic acid synthase.
 
 
 0.962
Krad_3029
PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: sma:SAV6853 putative shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family.
 
  
 0.958
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.957
Krad_3982
TIGRFAM: isochorismate synthase; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: bld:BLi03901 isochorismate synthase; RBL00457.
 
  
 0.947
Krad_3119
TIGRFAM: chorismate mutase; PFAM: Chorismate mutase of the AroH class; KEGG: nca:Noca_2499 chorismate mutase.
  
 
 0.946
Krad_3118
Prephenate dehydrogenase; PFAM: amino acid-binding ACT domain protein; Prephenate dehydrogenase; KEGG: art:Arth_1535 prephenate dehydrogenase.
 
 
 0.929
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.883
Krad_3445
PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: rha:RHA1_ro01564 shikimate 5-dehydrogenase.
 
  
 0.852
Your Current Organism:
Kineococcus radiotolerans
NCBI taxonomy Id: 266940
Other names: K. radiotolerans SRS30216 = ATCC BAA-149, Kineococcus radiotolerans ATCC BAA-149, Kineococcus radiotolerans ATCC BAA-149 = SRS30216, Kineococcus radiotolerans SRS30216, Kineococcus radiotolerans SRS30216 = ATCC BAA-149, Kineococcus-like str. SRS30216
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