STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnDBifunctional [protein-PII] modification enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (919 aa)    
Predicted Functional Partners:
glnB
Nitrogen regulatory protein P-II; Annotated by: sma3s; COG0347; Belongs to the P(II) protein family.
 
 
 0.978
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
       0.825
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.770
glnB2
Nitrogen regulatory protein P-II; Annotated by: sma3s; COG0347; Belongs to the P(II) protein family.
 
 
 
 0.723
maeB
NADP-dependent malic enzyme; Annotated by: sma3s; COG0281; COG0280.
       0.712
gltB
GLTS alpha chain; Annotated by: sma3s; COG0069; COG0067; COG0070.
     
 0.704
bamA
Outer membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.595
glnA
Glutamate--ammonia ligase; Annotated by: sma3s; COG0174.
 
   
 0.547
AMG74599.1
Putative PAS/PAC sensor protein; Annotated by: sma3s; COG3852.
   
 
 0.518
ntrB
Nitrogen regulation protein NtrB; Annotated by: sma3s; COG3852.
  
 
 
 0.511
Your Current Organism:
Sphingopyxis granuli
NCBI taxonomy Id: 267128
Other names: KCTC 12209, NBRC 100800, S. granuli, Sphingopyxis granuli Kim et al. 2011, Sphingopyxis sp. TFA, strain Kw07
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