node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMG73222.1 | aspC | SGRAN_0828 | SGRAN_3427 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | 0.918 |
AMG73222.1 | hisC | SGRAN_0828 | SGRAN_4157 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Histidinol-phosphate aminotransferase; Annotated by: sma3s; COG0079; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.925 |
AMG73222.1 | tyrC | SGRAN_0828 | SGRAN_4158 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Cyclohexadienyl dehydrogenase; Annotated by: sma3s; COG0287. | 0.912 |
aspC | AMG73222.1 | SGRAN_3427 | SGRAN_0828 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | 0.918 |
aspC | hisC | SGRAN_3427 | SGRAN_4157 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Histidinol-phosphate aminotransferase; Annotated by: sma3s; COG0079; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.922 |
aspC | tyrC | SGRAN_3427 | SGRAN_4158 | Aspartate aminotransferase; Annotated by: sma3s; COG0436. | Cyclohexadienyl dehydrogenase; Annotated by: sma3s; COG0287. | 0.922 |
hisA | hisB | SGRAN_3684 | SGRAN_3686 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | 0.998 |
hisA | hisC | SGRAN_3684 | SGRAN_4157 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | Histidinol-phosphate aminotransferase; Annotated by: sma3s; COG0079; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.938 |
hisA | hisD | SGRAN_3684 | SGRAN_1679 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |
hisA | hisF | SGRAN_3684 | SGRAN_3683 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SGRAN_3684 | SGRAN_1678 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.987 |
hisA | hisH | SGRAN_3684 | SGRAN_3685 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | IGP synthase glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SGRAN_3684 | SGRAN_2325 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | SGRAN_3686 | SGRAN_3684 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Annotated by: sma3s; COG0106. | 0.998 |
hisB | hisC | SGRAN_3686 | SGRAN_4157 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | Histidinol-phosphate aminotransferase; Annotated by: sma3s; COG0079; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | SGRAN_3686 | SGRAN_1679 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisF | SGRAN_3686 | SGRAN_3683 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SGRAN_3686 | SGRAN_1678 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.985 |
hisB | hisH | SGRAN_3686 | SGRAN_3685 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | IGP synthase glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | SGRAN_3686 | SGRAN_2325 | Imidazoleglycerol-phosphate dehydratase; Annotated by: sma3s; COG0131. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.987 |