STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argHArgininosuccinate lyase; Citation: R. Cohen Kupiec et. al. FEMS Microbiol Lett. 173, 231-238 (1999). (481 aa)    
Predicted Functional Partners:
argG
Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 0.999
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
  
  
 0.996
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.996
argD
Aminotransferase (subgroup II) similar to Acetylornithine aminotransferase; Citation: Billheimer JT, Shen MY, Carnevale HN, Horton HR, Jones EE.(1979). Arch Biochem Biophys 195:401-13; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.994
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
  
 0.991
argJ
Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
  
  
 0.990
purB
Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
0.934
MMP0339
NUDIX hydrolase; Citation: J. Bio. Chem. (1998) 273: 20924-20928.
    
 0.912
carB
Carbamoyl-phosphate synthase large chain; Citation: Nicoloff H, Hubert JC, Bringel F. (2000). J. Bacteriol. 182:3416-3422; Belongs to the CarB family.
  
  
 0.908
mdh
Malate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.890
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: high (82%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.