node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0089 | cbiJ | MMP0089 | MMP0599 | Conserved hypothetical protein. | Precorrin-6x reductase CbiJ/CobK. | 0.552 |
MMP0089 | cbiL | MMP0089 | MMP0319 | Conserved hypothetical protein. | Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. | 0.968 |
MMP0089 | cbiX(s) | MMP0089 | MMP0164 | Conserved hypothetical protein. | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.988 |
MMP0089 | gtrA | MMP0089 | MMP0088 | Conserved hypothetical protein. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.976 |
MMP0089 | hemB | MMP0089 | MMP1258 | Conserved hypothetical protein. | Delta-aminolevulinic acid dehydratase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the ALAD family. | 0.514 |
MMP0089 | hemC | MMP0089 | MMP0872 | Conserved hypothetical protein. | Porphobilinogen deaminase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82. | 0.730 |
MMP0089 | hemD | MMP0089 | MMP0394 | Conserved hypothetical protein. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.891 |
MMP0089 | hemL | MMP0089 | MMP0224 | Conserved hypothetical protein. | Glutamate-1-semialdehyde aminotransferase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.551 |
MMP0089 | hmgA | MMP0089 | MMP0087 | Conserved hypothetical protein. | Hydroxymethylglutaryl-coenzyme A reductase:3-hydroxy-3-methylglutaryl Coenzyme A reductase; Citation: Protein Expr Purif. 1999 Dec;17(3):435-42, Mol Biol Evol. 2001 Jul;18(7):1378-88; Belongs to the HMG-CoA reductase family. | 0.789 |
cbiJ | MMP0089 | MMP0599 | MMP0089 | Precorrin-6x reductase CbiJ/CobK. | Conserved hypothetical protein. | 0.552 |
cbiJ | cbiL | MMP0599 | MMP0319 | Precorrin-6x reductase CbiJ/CobK. | Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. | 0.998 |
cbiJ | cbiX(s) | MMP0599 | MMP0164 | Precorrin-6x reductase CbiJ/CobK. | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.846 |
cbiJ | gtrA | MMP0599 | MMP0088 | Precorrin-6x reductase CbiJ/CobK. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.878 |
cbiJ | hemB | MMP0599 | MMP1258 | Precorrin-6x reductase CbiJ/CobK. | Delta-aminolevulinic acid dehydratase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the ALAD family. | 0.513 |
cbiJ | hemC | MMP0599 | MMP0872 | Precorrin-6x reductase CbiJ/CobK. | Porphobilinogen deaminase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82. | 0.843 |
cbiJ | hemD | MMP0599 | MMP0394 | Precorrin-6x reductase CbiJ/CobK. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.545 |
cbiJ | hemL | MMP0599 | MMP0224 | Precorrin-6x reductase CbiJ/CobK. | Glutamate-1-semialdehyde aminotransferase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.501 |
cbiL | MMP0089 | MMP0319 | MMP0089 | Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. | Conserved hypothetical protein. | 0.968 |
cbiL | cbiJ | MMP0319 | MMP0599 | Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-6x reductase CbiJ/CobK. | 0.998 |
cbiL | cbiX(s) | MMP0319 | MMP0164 | Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.986 |