Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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MMP0140Conserved hypothetical protein; HypF family; Citation: Mol. Microbiol. 8 (3); 471-481 (1993). (771 aa)    
Predicted Functional Partners:
hypE
Hydrogenase expression/formation protein.
 
 
 0.993
hypD
Hydrogenase expression/formation protein.
 
  
 0.991
hypA
Hydrogenase accessory protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.974
MMP1330
Hydrogenase expression/formation protein (HUPF/HYPC).
 
 
 0.943
MMP1520
Hydrogenase nickel incorporation protein HypB; ATP/GTP-binding site motif A (P-loop):HypB/UreG, nucleotide-binding:Hydrogenase accessory protein HypB.
 
  
 0.937
fruA
Coenzyme F420-reducing hydrogenase subunit alpha; Contains selenocysteine; membrane-bound; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Halboth,S., Klein (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 
 0.836
frcA
Coenzyme F420-reducing hydrogenase subunit alpha; Cytoplasmic, selenium independent; Citation: Muth, E. et al. 1987. Eur. J. Biochem. 169:571-7. Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.834
gldA
Glycerol dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family.
       0.827
MMP1185
Hydrogen uptake protein:Hydrogenase maturation protease HycI.
 
   
 0.757
vhcA
Coenzyme F420-non-reducing hydrogenase subunit alpha; Selenium independent; Citation: Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.726
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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