Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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co-expression
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gene co-occurrence
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MMP0142Thiamine pyrophosphate dependent enzyme related to acetolactate synthase; Citation: Bowen T.L. et al, Gene 188, 77 (1997); Belongs to the TPP enzyme family. (501 aa)    
Predicted Functional Partners:
ilvN
Acetohydroxyacid synthase small subunit.
 0.997
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.982
MMP0613
Alpha-acetolactate decarboxylase.
 
 
 0.972
MMP0141
Conserved archaeal protein; Probable Zn finger protein; Prokaryotic DNA topoisomerase I-related (C-term).
  
  
 0.958
cimA
(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.957
leuB
3-isopropylmalate dehydrogenase; Citation: J Bact 182:5013.
  
 0.953
korB
2-oxoglutarate oxidoreductase beta subunit; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8.
  
 
 0.926
porB
Pyruvate oxidoreductase (synthase) subunit beta; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8; Lin, WC et al, Arch Microbiol 179:444 (2003).
  
 
 0.926
porA
Pyruvate oxidoreductase (synthase) subunit alpha; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8; Lin, WC et al, Arch Microbiol 179:444 (2003).
  
 
 0.925
porC
Pyruvate oxidoreductase (synthase) subunit gamma; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8; Lin, WC et al, Arch Microbiol 179:444 (2003).
  
 
 0.922
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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