Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MMP0203Conserved hypothetical protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (77 aa)    
Predicted Functional Partners:
MMP1174
Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 0.954
MMP1332
NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
 0.863
MMP0202
Conserved hypothetical protein.
 
  
 0.862
msrA
Protein methionine-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 0.847
trxB
Thioredoxin reductase.
  
 
 0.759
MMP0176
CDC48 cell division cycle protein family member; ATP/GTP-binding site motif A (P-loop); Citation: Mol. Gen. Genet. (1999) 262: 559-567, Cell (1995) 82: 885-893.
  
 0.754
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
   
 0.726
MMP0204
Conserved hypothetical protein; Contains flavoprotein domain.
  
  
 0.720
MMP0418
Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family.
   
 
 0.698
MMP1642
ATP/GTP-binding site motif A (P-loop):Small GTP-binding protein domain.
  
 0.696
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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