Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hemLGlutamate-1-semialdehyde aminotransferase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (427 aa)    
Predicted Functional Partners:
gtrA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.997
hemB
Delta-aminolevulinic acid dehydratase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the ALAD family.
 
 
 0.997
hemC
Porphobilinogen deaminase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82.
  
 0.979
hemD
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.881
MMP0223
Conserved hypothetical protein.
  
    0.864
cobA
uroporphyrin-III C-methyltransferase; Citation: J Bacteriol. 1991 Aug;173(15):4637-45; Belongs to the precorrin methyltransferase family.
     
 0.855
fucA
Class II aldolase/adducin, N-terminal; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.
      0.855
MMP0222
Conserved hypothetical archaeal protein.
       0.781
MMP0089
Conserved hypothetical protein.
     
 0.740
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate.
     
 0.731
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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