Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP0246Conserved hypothetical archaeal protein. (88 aa)    
Predicted Functional Partners:
MMP0248
DNA-directed RNA polymerase related protein.
  
    0.994
MMP0247
Conserved hypothetical archaeal protein; Probably involved in the biogenesis of the ribosome.
  
    0.969
rpl37ae
Ribosomal L37ae protein; Binds to the 23S rRNA.
  
    0.930
MMP0250
Conserved hypothetical protein.
  
    0.913
pfdB
Prefoldin beta subunit (GimC beta subunit); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
    0.847
rpl18a
Ribosomal LX protein.
       0.827
MMP0415
Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...]
     
 0.819
psmA
Proteasome, subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
       0.799
MMP0244
Conserved hypothetical protein.
       0.782
MMP0017
Conserved hypothetical protein.
       0.739
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.