Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
hypEHydrogenase expression/formation protein. (334 aa)    
Predicted Functional Partners:
hypD
Hydrogenase expression/formation protein.
 
 0.999
MMP0140
Conserved hypothetical protein; HypF family; Citation: Mol. Microbiol. 8 (3); 471-481 (1993).
 
 
 0.993
MMP1330
Hydrogenase expression/formation protein (HUPF/HYPC).
 
 
 0.983
hypA
Hydrogenase accessory protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.972
MMP1520
Hydrogenase nickel incorporation protein HypB; ATP/GTP-binding site motif A (P-loop):HypB/UreG, nucleotide-binding:Hydrogenase accessory protein HypB.
 
  
 0.830
slyD
Peptidylprolyl isomerase, FKBP-type.
   
  
 0.691
fruA
Coenzyme F420-reducing hydrogenase subunit alpha; Contains selenocysteine; membrane-bound; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Halboth,S., Klein (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.674
ehbN
Energy conserving hydrogenase B large subunit; Citation: Tersteegen, A. and R. Hedderich. 1999. Eur. J. Biochem. 264:930-43.
  
  
 0.668
ehaO
Energy conserving hydrogenase A large subunit; Citation: Tersteegen, A. and R. Hedderich. 1999. Eur. J. Biochem. 264:930-43.
     
 0.653
MMP0271
ATP binding putative nickel incorporation protein.
  
  
 0.647
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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