Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase accessory protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (126 aa)    
Predicted Functional Partners:
MMP1520
Hydrogenase nickel incorporation protein HypB; ATP/GTP-binding site motif A (P-loop):HypB/UreG, nucleotide-binding:Hydrogenase accessory protein HypB.
 
 
 0.990
hypD
Hydrogenase expression/formation protein.
 
  
 0.986
MMP0140
Conserved hypothetical protein; HypF family; Citation: Mol. Microbiol. 8 (3); 471-481 (1993).
 
   
 0.974
hypE
Hydrogenase expression/formation protein.
 
  
 0.972
MMP0300
Conserved hypothetical protein.
  
    0.966
MMP0704
ParA type ATPase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
   
 
 0.938
MMP0271
ATP binding putative nickel incorporation protein.
  
 
 0.908
MMP1330
Hydrogenase expression/formation protein (HUPF/HYPC).
 
  
 0.908
vhcA
Coenzyme F420-non-reducing hydrogenase subunit alpha; Selenium independent; Citation: Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
 
 0.897
vhuA
F420-non-reducing hydrogenase subunit alpha; Selenium dependent; Citation: Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224.
  
 
 0.897
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (14%) [HD]