STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase accessory protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (126 aa)    
Predicted Functional Partners:
MMP1520
Hydrogenase nickel incorporation protein HypB; ATP/GTP-binding site motif A (P-loop):HypB/UreG, nucleotide-binding:Hydrogenase accessory protein HypB.
 
 
 0.995
MMP0300
Conserved hypothetical protein.
  
    0.967
hypD
Hydrogenase expression/formation protein.
 
  
 0.930
MMP0704
ParA type ATPase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
  
 
 0.929
MMP0271
ATP binding putative nickel incorporation protein.
  
 
 0.928
hypE
Hydrogenase expression/formation protein.
 
  
 0.914
fruA
Coenzyme F420-reducing hydrogenase subunit alpha; Contains selenocysteine; membrane-bound; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Halboth,S., Klein (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.902
MMP0140
Conserved hypothetical protein; HypF family; Citation: Mol. Microbiol. 8 (3); 471-481 (1993).
 
   
 0.894
vhcA
Coenzyme F420-non-reducing hydrogenase subunit alpha; Selenium independent; Citation: Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
 
 0.893
vhuA
F420-non-reducing hydrogenase subunit alpha; Selenium dependent; Citation: Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224.
  
 
 0.893
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.