Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
actRadical-activating enzyme. (268 aa)    
Predicted Functional Partners:
nrdD
Anaerobic Ribonucleoside-triphosphate reductase; Eliasson R, Fontecave M, Jornvall H, Krook M, Pontis E, Reichard P. (1990)Proc Natl Acad Sci U S A 87:3314-8; Citation: Science 273 (5278); 1058-1073 (1996).
  
 0.992
mptE
Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
  
    0.798
thiI
Thiamine biosynthesis protein:THUMP domain; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.672
MMP1282
Conseved hypothetical protein NTP-binding; Belongs to the UPF0200 family.
       0.669
hisC
Histidinol-phosphate aminotransferase; Citation: Conover RK, Doolittle WF. (1990) J Bacteriol 172:3244-9.
  
  
 0.659
MMP0581
Conserved hypothetical protein.
  
    0.620
MMP0802
Iron-containing alcohol dehydrogenase.
  
  
 0.577
moaA
MoaA/nifB/pqqE family; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
  
 0.576
aroQ
Chorismate mutase; Citation: MacBeath G, Kast P, Hilvert D. (1998). Biochemistry 37:10062-73.
       0.541
rps17e
30S ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family.
 
     0.492
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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