Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rlmE23 S ribosomal RNA methyltransferase related; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (258 aa)    
Predicted Functional Partners:
MMP0596
RNA 2'-O-methyl modification protein (NOP5/NOP56); Citation: Hickey, A.J., Macario, A.J.L., and Conway de Macario, E. Gene 253:77-85,2000.
  
 0.973
MMP0901
ATP/GTP-binding site motif A (P-loop):Small GTP-binding protein domain.
   
 
 0.948
rps8e
SSU ribosomal protein S8E.
  
 
 0.927
MMP1334
Solute-binding protein/glutamate receptor:ATP/GTP-binding site motif A (P-loop):GTP-binding protein, HSR1-related:GTP-binding.
   
 
 0.922
rpmD
LSU ribosomal protein L30P.
   
 
 0.919
MMP0247
Conserved hypothetical archaeal protein; Probably involved in the biogenesis of the ribosome.
   
 
 0.905
MMP1126
Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
 
 0.898
MMP0016
Conserved hypothetical protein.
  
 
 0.896
aIF6
Translation initiation factor IF6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
  
 
 0.885
rpl7ae
Ribosomal protein L7AE:Ribosomal protein L7Ae/L30e/S12e/Gadd45; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, this subunit dramatically stimulates RNase P activity.
   
 0.885
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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