Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdhMalate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate. (314 aa)    
Predicted Functional Partners:
fumA
Fumarate hydratase.
  
 
 0.989
pycB
Pyruvate carboxylase subunit B; Citation: JBC 273:5155.
  
 
 0.985
MMP0644
Cation efflux protein.
  
    0.979
MMP1072
Aminotransferase (subgroup I) similar to Aromatic Aminotransferase; Ward DE, de Vos WM, van der Oost J (2002) Archaea 1:133-141; Citation: Matsui I, Matsui E, Sakai Y, Kikuchi H, Kawarabayasi Y, Ura H, Kawaguchi S, Kuramitsu S, Harata K. (2000)J Biol Chem 275:4871-9.
  
 0.979
MMP1548
Fe-S type hydro-lyases tartrate/fumarate beta region.
  
 
 0.979
sucC
succinate-CoA ligase (ADP-forming), beta chain.
  
 0.978
hsp60
Chaperonin GroEL (thermosome, HSP60 family); Belongs to the TCP-1 chaperonin family.
  
 0.954
MMP1605
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.952
frdA
Fumarate reductase/succinate dehydrogenase, flavoprotein subunit.
 
 
 0.936
sucD
succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.934
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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