STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate. (314 aa)    
Predicted Functional Partners:
fumA
Fumarate hydratase.
  
 
 0.994
comC
L-sulfolactate dehydrogenase/(S)-hydroxyglutaric acid dehydrogenase; Citation: J. Bacteriol. 182:3688-3692(2000).
  
 
 0.986
MMP1548
Fe-S type hydro-lyases tartrate/fumarate beta region.
  
 
 0.986
pycB
Pyruvate carboxylase subunit B; Citation: JBC 273:5155.
  
 
 0.982
MMP0644
Cation efflux protein.
  
    0.980
sucD
succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.965
sucC
succinate-CoA ligase (ADP-forming), beta chain.
  
 
 0.959
MMP1072
Aminotransferase (subgroup I) similar to Aromatic Aminotransferase; Ward DE, de Vos WM, van der Oost J (2002) Archaea 1:133-141; Citation: Matsui I, Matsui E, Sakai Y, Kikuchi H, Kawarabayasi Y, Ura H, Kawaguchi S, Kuramitsu S, Harata K. (2000)J Biol Chem 275:4871-9.
  
 0.938
rpl4
LSU Ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.935
MMP1605
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.933
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.