Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
frcBCoenzyme F420-reducing hydrogenase subunit beta; Cytoplasmic, selenium independent; Citation: Muth, E. et al. 1987. Eur. J. Biochem. 169:571-7. Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A. (282 aa)    
Predicted Functional Partners:
frcG
Coenzyme F420-reducing hydrogenase subunit gamma; Cytoplasmic, selenium independent; Citation: Muth, E. et al. 1987. Eur. J. Biochem. 169:571-7. Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A.
 0.999
frcA
Coenzyme F420-reducing hydrogenase subunit alpha; Cytoplasmic, selenium independent; Citation: Muth, E. et al. 1987. Eur. J. Biochem. 169:571-7. Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 0.998
fruG
Coenzyme F420-reducing hydrogenase subunit gamma; Membrane-bound, selenium dependent; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224.
 0.996
fruA
Coenzyme F420-reducing hydrogenase subunit alpha; Contains selenocysteine; membrane-bound; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Halboth,S., Klein (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 0.994
frcD
Coenzyme F420-reducing hydrogenase subunit delta; Cytoplasmic, selenium independent; Citation: Muth, E. et al. 1987. Eur. J. Biochem. 169:571-7. Rossmann, R. et al. 1995. Eur. J. Biochem. 227:545-50. Halboth,S., Klein,A.
 
 
 0.992
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
   
 
 0.956
vhcA
Coenzyme F420-non-reducing hydrogenase subunit alpha; Selenium independent; Citation: Berghofer, Y. et al. 1994. Mol. Gen. Genet. 242:369-373. Halboth,S., Klein,A. (1992) Mol. Gen. Genet. 233:217-224; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
 
 0.952
mer
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
 
 
 0.943
fruD
Coenzyme F420-reducing hydrogenase delta subunit; Membrane-bound, selenium dependent; Citation: Brodersen, J. et al. 1999. Arch. Microbiol. 171:115-21. Rossmann, R., et al. 1995. Eur. J. Biochem. 2274:545-50. Halboth,S., K.
 
 
 0.939
MMP1337
Hydrogenase maturation protease, related; Related to frcD and fruD; Citation: Rossmann, R. et al. 1995. Eur. J. Biochem. 227:545-50.
    
 0.917
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.