Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MMP0829Coenzyme B12-binding:Cobalamin-dependent methionine synthase, B12-binding. (219 aa)    
Predicted Functional Partners:
mtbC
Coenzyme B12-binding:Cobalamin-dependent methionine synthase, B12-binding.
  
 
 
0.990
mtaA-2
Uroporphyrinogen decarboxylase (URO-D).
  
 0.979
mtbA
Uroporphyrinogen decarboxylase (URO-D).
 
  
 0.974
mtaA
Uroporphyrinogen decarboxylase (URO-D).
  
 0.970
MMP0114
Conserved hypothetical protein.
  
    0.922
MMP0832
Conserved Hypothetical Protein.
 
  
 0.919
mtrH
N5-methyltetrahydromethanopterin: methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
    
 0.916
mcrB
Methyl-coenzyme M reductase I, beta subunit; Citation: J. Bacteriol. 1994; 176: 6384-6391. Eur. J. Biochem. 1990; 194: 871-877.
    
 0.910
mcrA
Methyl-coenzyme M reductase I, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
     
 0.908
mcrG
Methyl-coenzyme M reductase I, gamma subunit; Citation: J. Bacterio. 1994; 176: 6384-6391. Eur. J. Biochem. 1990; 194: 871-877.
     
 0.907
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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