Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
MMP0874SAM (and some other nucleotide) binding motif. (265 aa)    
Predicted Functional Partners:
MMP0646
Hypothetical protein.
  
    0.924
MMP1177
Putative iron transport system substrate-binding protein, C-term half.
  
    0.677
MMP1176
Putative iron transport system substrate-binding protein, N-term half.
  
    0.672
MMP0457
Probable ATP dependent RNA helicase; Citation: Mol. Cell 2001; 8:251-62. Nucleic Acids Res. 1999; 27:3811-20. Prog. Nucleic Acid Res. Biol. 2002; 72:307-31, PNAS (2001) 98:; Belongs to the DEAD box helicase family.
     
 0.643
MMP0076
Conserved hypothetical protein.
      
 0.634
mdh
Malate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate.
   
    0.605
MMP1175
Unnamed protein product.
 
    0.596
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
   
  
 0.474
MMP0644
Cation efflux protein.
   
    0.462
hsp60
Chaperonin GroEL (thermosome, HSP60 family); Belongs to the TCP-1 chaperonin family.
   
  
 0.455
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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