node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DP1 | dnaB | MMP0008 | MMP0380 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | 0.999 |
DP1 | exoA | MMP0008 | MMP1012 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Exonuclease III; Citation: J. Bact. (1982) 151: 351-357, PNAS (1986) 83: 7731-7735. | 0.722 |
DP1 | fen-1 | MMP0008 | MMP1313 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.994 |
DP1 | lig | MMP0008 | MMP0970 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.931 |
DP1 | mre11 | MMP0008 | MMP1340 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.671 |
DP1 | pcnA | MMP0008 | MMP1711 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.999 |
DP1 | rad50 | MMP0008 | MMP1341 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.604 |
DP1 | rfcA | MMP0008 | MMP0427 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.937 |
DP1 | rfcB | MMP0008 | MMP0322 | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.812 |
MMP1142 | lig | MMP1142 | MMP0970 | Metallo-phosphoesterase:Serine/threonine- specificprotein phosphatase. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.800 |
dnaB | DP1 | MMP0380 | MMP0008 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.999 |
dnaB | exoA | MMP0380 | MMP1012 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | Exonuclease III; Citation: J. Bact. (1982) 151: 351-357, PNAS (1986) 83: 7731-7735. | 0.839 |
dnaB | fen-1 | MMP0380 | MMP1313 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.995 |
dnaB | lig | MMP0380 | MMP0970 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.960 |
dnaB | mre11 | MMP0380 | MMP1340 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.826 |
dnaB | pcnA | MMP0380 | MMP1711 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.999 |
dnaB | rad50 | MMP0380 | MMP1341 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.952 |
dnaB | rfcA | MMP0380 | MMP0427 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.988 |
dnaB | rfcB | MMP0380 | MMP0322 | DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.957 |
exoA | DP1 | MMP1012 | MMP0008 | Exonuclease III; Citation: J. Bact. (1982) 151: 351-357, PNAS (1986) 83: 7731-7735. | DNA polymerase, archaeal type II, small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.722 |